2-((3-(5-(3-(cyclopropylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)propyl)(2,2,2-trifluoroethyl)amino)ethanol

Base Information

Chemical Name:2-((3-(5-(3-(cyclopropylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)propyl)(2,2,2-trifluoroethyl)amino)ethanol
CAS No.:1020205-46-2
Molecular Formula:C₂₈H₃₀F₃N₃O₄S
Molecular Weight:561.625
Hs Code.:

Synonyms:2-((3-(5-(3-(cyclopropylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)propyl)(2,2,2-trifluoroethyl)amino)ethanol

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Chemical Property of 2-((3-(5-(3-(cyclopropylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)propyl)(2,2,2-trifluoroethyl)amino)ethanol

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Technology Process of 2-((3-(5-(3-(cyclopropylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)propyl)(2,2,2-trifluoroethyl)amino)ethanol

There total 5 articles about 2-((3-(5-(3-(cyclopropylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)propyl)(2,2,2-trifluoroethyl)amino)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1020204-12-9
3-(cyclopropylsulfonyl)phenylboronic acid

: 1192145-77-9
2-((3-(5-chloro-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)propyl)(2,2,2-trifluoroethyl)amino)ethanol

: 1020205-46-2
2-((3-(5-(3-(cyclopropylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)propyl)(2,2,2-trifluoroethyl)amino)ethanol

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water; for 1h; Reflux;

Reference yield:

: 1192145-74-6
4-chloro-1-(3-chloropropoxy)-2-iodobenzene

: 1020205-46-2
2-((3-(5-(3-(cyclopropylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)propyl)(2,2,2-trifluoroethyl)amino)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: potassium iodide / ISOPROPYLAMIDE / 80 °C

2: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / ISOPROPYLAMIDE / 3 h / 80 °C / Inert atmosphere

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / palladium diacetate; CyJohnPhos / ISOPROPYLAMIDE / 4 h / 80 - 155 °C / Inert atmosphere

4: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine / 1,4-dioxane; water / 1 h / Reflux

With caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; CyJohnPhos; tricyclohexylphosphine; In 1,4-dioxane; ISOPROPYLAMIDE; water;

Reference yield:

: 1192145-75-7
2-((3-(4-chloro-2-iodophenoxy)propyl)(2,2,2-trifluoroethyl)amino)ethanol

: 1020205-46-2
2-((3-(5-(3-(cyclopropylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-yloxy)propyl)(2,2,2-trifluoroethyl)amino)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / ISOPROPYLAMIDE / 3 h / 80 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / palladium diacetate; CyJohnPhos / ISOPROPYLAMIDE / 4 h / 80 - 155 °C / Inert atmosphere

3: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine / 1,4-dioxane; water / 1 h / Reflux

With caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; CyJohnPhos; tricyclohexylphosphine; In 1,4-dioxane; ISOPROPYLAMIDE; water;