[2-bromo-4-[[(4,4'-dimethoxytrityl)oxy]methyl]benzyl]dimethylamine

Base Information

• Chemical Name: [2-bromo-4-[[(4,4'-dimethoxytrityl)oxy]methyl]benzyl]dimethylamine
• CAS No.: 866722-01-2
• Molecular Formula: C₃₁H₃₂BrNO₃
• Molecular Weight: 546.504
• Mol file: 866722-01-2.mol

Synonyms:[2-bromo-4-[[(4,4'-dimethoxytrityl)oxy]methyl]benzyl]dimethylamine

Chemical Property of [2-bromo-4-[[(4,4'-dimethoxytrityl)oxy]methyl]benzyl]dimethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-bromo-4-[[(4,4'-dimethoxytrityl)oxy]methyl]benzyl]dimethylamine

There total 3 articles about [2-bromo-4-[[(4,4'-dimethoxytrityl)oxy]methyl]benzyl]dimethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

[3-bromo-4-[(dimethylamino)methyl]phenyl]methanol (866721-96-2) + 4,4'-dimethoxytrityl chloride (40615-36-9) → [2-bromo-4-[[(4,4'-dimethoxytrityl)oxy]methyl]benzyl]dimethylamine (866722-01-2)

Guidance literature:

With pyridine; at 20 ℃; for 1h;

DOI:10.1021/jo051202m

Reference yield:

3-bromo-4-(bromomethyl)benzoic acid (866721-92-8) → [2-bromo-4-[[(4,4'-dimethoxytrityl)oxy]methyl]benzyl]dimethylamine (866722-01-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / BH₃*THF / tetrahydrofuran / 1.5 h / 20 °C

2: 99 percent / tetrahydrofuran / 1.5 h / 20 °C

3: 81 percent / pyridine / 1 h / 20 °C

With pyridine; borane-THF; In tetrahydrofuran;

DOI:10.1021/jo051202m

Reference yield:

3-bromo-4-methylbenzoic acid (7697-26-9) → [2-bromo-4-[[(4,4'-dimethoxytrityl)oxy]methyl]benzyl]dimethylamine (866722-01-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 73 percent / N-bromosuccinimide; 2,2'-azobis(isobutyronitrile) / CCl₄ / 1 h / Heating

2: 69 percent / BH₃*THF / tetrahydrofuran / 1.5 h / 20 °C

3: 99 percent / tetrahydrofuran / 1.5 h / 20 °C

4: 81 percent / pyridine / 1 h / 20 °C

With pyridine; N-Bromosuccinimide; borane-THF; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; tetrachloromethane;

DOI:10.1021/jo051202m

upstream raw materials:

[3-bromo-4-[(dimethylamino)methyl]phenyl]methanol

4,4'-dimethoxytrityl chloride

3-bromo-4-(bromomethyl)benzoic acid

3-bromo-4-methylbenzoic acid