ethyl 3-{[3-(ethyloxy)-3-oxopropanoyl][2-(2-oxo-1-pyrrolidinyl)ethyl]amino}-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate

Base Information

Chemical Name:ethyl 3-{[3-(ethyloxy)-3-oxopropanoyl][2-(2-oxo-1-pyrrolidinyl)ethyl]amino}-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate
CAS No.:863443-84-9
Molecular Formula:C₂₆H₃₀FN₃O₆
Molecular Weight:499.539
Hs Code.:

Synonyms:ethyl 3-{[3-(ethyloxy)-3-oxopropanoyl][2-(2-oxo-1-pyrrolidinyl)ethyl]amino}-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate

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Chemical Property of ethyl 3-{[3-(ethyloxy)-3-oxopropanoyl][2-(2-oxo-1-pyrrolidinyl)ethyl]amino}-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate

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Technology Process of ethyl 3-{[3-(ethyloxy)-3-oxopropanoyl][2-(2-oxo-1-pyrrolidinyl)ethyl]amino}-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate

There total 5 articles about ethyl 3-{[3-(ethyloxy)-3-oxopropanoyl][2-(2-oxo-1-pyrrolidinyl)ethyl]amino}-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 863442-96-0
2-(2-oxopyrrolidin-1-yl)acetaldehyde

: 863442-92-6
ethyl 3-amino-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate

: 584-08-7
potassium carbonate

: 863443-84-9
ethyl 3-{[3-(ethyloxy)-3-oxopropanoyl][2-(2-oxo-1-pyrrolidinyl)ethyl]amino}-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; acetic acid; ethyl acetate;

Reference yield:

: 863442-92-6
ethyl 3-amino-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate

: 863443-84-9
ethyl 3-{[3-(ethyloxy)-3-oxopropanoyl][2-(2-oxo-1-pyrrolidinyl)ethyl]amino}-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dimethylsulfide borane complex; acetic acid / dichloromethane

2: 1,2-dichloro-ethane / Reflux

With dimethylsulfide borane complex; acetic acid; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2011.08.082

Reference yield:

: 863442-96-0
2-(2-oxopyrrolidin-1-yl)acetaldehyde

: 863443-84-9
ethyl 3-{[3-(ethyloxy)-3-oxopropanoyl][2-(2-oxo-1-pyrrolidinyl)ethyl]amino}-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dimethylsulfide borane complex; acetic acid / dichloromethane

2: 1,2-dichloro-ethane / Reflux

With dimethylsulfide borane complex; acetic acid; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2011.08.082