6-{3-[2-oxo-2-(2-phenyl-2,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethyl]-3,8-diazabicyclo[3.2.1]oct-8-yl}nicotinic acid methyl ester

Base Information

Chemical Name:6-{3-[2-oxo-2-(2-phenyl-2,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethyl]-3,8-diazabicyclo[3.2.1]oct-8-yl}nicotinic acid methyl ester
CAS No.:1279840-67-3
Molecular Formula:C₂₇H₃₀N₆O₃
Molecular Weight:486.574
Hs Code.:

Synonyms:6-{3-[2-oxo-2-(2-phenyl-2,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethyl]-3,8-diazabicyclo[3.2.1]oct-8-yl}nicotinic acid methyl ester

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Chemical Property of 6-{3-[2-oxo-2-(2-phenyl-2,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethyl]-3,8-diazabicyclo[3.2.1]oct-8-yl}nicotinic acid methyl ester

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Technology Process of 6-{3-[2-oxo-2-(2-phenyl-2,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethyl]-3,8-diazabicyclo[3.2.1]oct-8-yl}nicotinic acid methyl ester

There total 3 articles about 6-{3-[2-oxo-2-(2-phenyl-2,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethyl]-3,8-diazabicyclo[3.2.1]oct-8-yl}nicotinic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-[3,8-diazabicyclo[3.2.1]oct-8-yl]nicotinic acid methyl ester hydrochloride

: 1310796-17-8
2-chloro-1-(2-phenyl-2,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethanone

: 1279840-67-3
6-{3-[2-oxo-2-(2-phenyl-2,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethyl]-3,8-diazabicyclo[3.2.1]oct-8-yl}nicotinic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield:

: 1310796-19-0,1202645-17-7
(Z)-3-((dimethylamino)methylene)-4-oxopiperidine-1-carboxylic acid tert-butyl ester

: 1279840-67-3
6-{3-[2-oxo-2-(2-phenyl-2,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethyl]-3,8-diazabicyclo[3.2.1]oct-8-yl}nicotinic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 3 h / Reflux

1.2: 2 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 100 °C

With N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1279840-67-3
6-{3-[2-oxo-2-(2-phenyl-2,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethyl]-3,8-diazabicyclo[3.2.1]oct-8-yl}nicotinic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: Reflux

2.1: methanol / 3 h / Reflux

2.2: 2 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 100 °C

With N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;