4-(3,4-dichloro-6-fluorophenylamino)-7-methylpiperazine-6-aminoquinazoline

Base Information

Chemical Name:4-(3,4-dichloro-6-fluorophenylamino)-7-methylpiperazine-6-aminoquinazoline
CAS No.:863488-65-7
Molecular Formula:C₁₉H₁₉Cl₂FN₆
Molecular Weight:421.304
Hs Code.:

Synonyms:4-(3,4-dichloro-6-fluorophenylamino)-7-methylpiperazine-6-aminoquinazoline

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Chemical Property of 4-(3,4-dichloro-6-fluorophenylamino)-7-methylpiperazine-6-aminoquinazoline

Chemical Property:

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Technology Process of 4-(3,4-dichloro-6-fluorophenylamino)-7-methylpiperazine-6-aminoquinazoline

There total 4 articles about 4-(3,4-dichloro-6-fluorophenylamino)-7-methylpiperazine-6-aminoquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 863488-63-5
4-[(3,4-dichloro-6-fluorophenyl)amino]-7-methylpiperazine-6-nitroquinazoline

: 863488-65-7
4-(3,4-dichloro-6-fluorophenylamino)-7-methylpiperazine-6-aminoquinazoline

Guidance literature:: With hydrazine hydrate; nickel; In ethanol; water; isopropyl alcohol; at 80 ℃; for 0.416667h;
DOI:10.1021/jm0580196

Reference yield:

: 848006-02-0
4-[(3,4-dichloro-6-fluorophenyl)amino]-7-fluoro-6-nitroquinazoline

: 863488-65-7
4-(3,4-dichloro-6-fluorophenylamino)-7-methylpiperazine-6-aminoquinazoline

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / tetrahydrofuran / 20 h / Heating

2: 91 percent / hydrazine monohydrate / Raney Ni / ethanol; H₂O; propan-2-ol / 0.42 h / 80 °C

With hydrazine hydrate; nickel; In tetrahydrofuran; ethanol; water; isopropyl alcohol;
DOI:10.1021/jm0580196

Reference yield:

: 162012-70-6
4-chloro-7-fluoro-6-nitroquinazoline

: 863488-65-7
4-(3,4-dichloro-6-fluorophenylamino)-7-methylpiperazine-6-aminoquinazoline

Guidance literature:: Multi-step reaction with 3 steps

1: 30 percent / propan-2-ol; CH₂Cl₂ / 0.5 h / 20 °C

2: 91 percent / tetrahydrofuran / 20 h / Heating

3: 91 percent / hydrazine monohydrate / Raney Ni / ethanol; H₂O; propan-2-ol / 0.42 h / 80 °C

With hydrazine hydrate; nickel; In tetrahydrofuran; ethanol; dichloromethane; water; isopropyl alcohol;
DOI:10.1021/jm0580196