C₄₅H₆₆O₁₃Si₂

Base Information

• Chemical Name: C₄₅H₆₆O₁₃Si₂
• CAS No.: 118893-73-5
• Molecular Formula: C₄₅H₆₆O₁₃Si₂
• Molecular Weight: 871.182
• Mol file: 118893-73-5.mol

Synonyms:C₄₅H₆₆O₁₃Si₂

Chemical Property of C₄₅H₆₆O₁₃Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₅H₆₆O₁₃Si₂

There total 5 articles about C₄₅H₆₆O₁₃Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzoic acid (3S,4R,5R)-2-((R)-5-benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-(tert-butyl-dimethyl-silanyloxy)-5,6-dihydroxy-tetrahydro-pyran-3-yl ester (118893-70-2,119007-06-6) → C45H66O13Si2 (118893-73-5)

Guidance literature:

Multi-step reaction with 4 steps

1: conc. sulfuric acid, MgSO₄ / 12 h / 50 °C

2: 93 percent / H₂ / 20percent Pd(OH)2/C / ethanol / 5 h / 760 Torr

3: 73 percent / oxalyl chloride, dimethyl sulfoxide, triethylamine / CH₂Cl₂ / 0.5 h / -78 °C

4: Eu(hfc)3 / CDCl₃ / 60 h / Ambient temperature

With oxalyl dichloride; tris{3-(heptafluoropropylhydroxymethylene)-camphorato}europium(III); sulfuric acid; hydrogen; magnesium sulfate; dimethyl sulfoxide; triethylamine; palladium dihydroxide; In chloroform-d1; ethanol; dichloromethane;

DOI:10.1021/ja00188a038

Reference yield:

Benzoic acid (3aR,5R,6S,7S,7aR)-5-((4R,5S)-5-benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-7-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran-6-yl ester (118893-69-9) → C45H66O13Si2 (118893-73-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / H₂ / 20percent Pd(OH)2/C / ethanol / 5 h / 760 Torr

2: 73 percent / oxalyl chloride, dimethyl sulfoxide, triethylamine / CH₂Cl₂ / 0.5 h / -78 °C

3: Eu(hfc)3 / CDCl₃ / 60 h / Ambient temperature

With oxalyl dichloride; tris{3-(heptafluoropropylhydroxymethylene)-camphorato}europium(III); hydrogen; dimethyl sulfoxide; triethylamine; palladium dihydroxide; In chloroform-d1; ethanol; dichloromethane;

DOI:10.1021/ja00188a038

Reference yield:

Benzoic acid (3S,4R,5R)-2-((R)-3-benzyloxy-1,2-dihydroxy-propyl)-4-(tert-butyl-dimethyl-silanyloxy)-5,6-dihydroxy-tetrahydro-pyran-3-yl ester (118893-68-8,119007-05-5) → C45H66O13Si2 (118893-73-5)

Guidance literature:

Multi-step reaction with 5 steps

1: p-toluenesulfonic acid, MgSO₄ / 26 h / 50 °C

2: conc. sulfuric acid, MgSO₄ / 12 h / 50 °C

3: 93 percent / H₂ / 20percent Pd(OH)2/C / ethanol / 5 h / 760 Torr

4: 73 percent / oxalyl chloride, dimethyl sulfoxide, triethylamine / CH₂Cl₂ / 0.5 h / -78 °C

5: Eu(hfc)3 / CDCl₃ / 60 h / Ambient temperature

With oxalyl dichloride; tris{3-(heptafluoropropylhydroxymethylene)-camphorato}europium(III); sulfuric acid; hydrogen; magnesium sulfate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; palladium dihydroxide; In chloroform-d1; ethanol; dichloromethane;

DOI:10.1021/ja00188a038

upstream raw materials:

1-benzoyloxy-2-tert-butyldimethylsilyloxy-4-methoxybuta-1,3-diene

Benzoic acid (3aR,5R,6S,7S,7aR)-7-(tert-butyl-dimethyl-silanyloxy)-5-((4S,5R)-5-formyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran-6-yl ester

Benzoic acid (3aR,5R,6S,7S,7aR)-7-(tert-butyl-dimethyl-silanyloxy)-5-((4R,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran-6-yl ester

Benzoic acid (3S,4R,5R)-2-((R)-5-benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-(tert-butyl-dimethyl-silanyloxy)-5,6-dihydroxy-tetrahydro-pyran-3-yl ester

Downstream raw materials:

C₃₈H₄₈O₁₂Si

C₃₈H₄₈O₁₂Si