(-)-2-methylpropane-2-sulfonic acid [(1S,3S)-3-amino-4-benzyloxy-3-methyl-1-((E)-styryl)butyl]amide

Base Information

• Chemical Name: (-)-2-methylpropane-2-sulfonic acid [(1S,3S)-3-amino-4-benzyloxy-3-methyl-1-((E)-styryl)butyl]amide
• CAS No.: 873695-41-1
• Molecular Formula: C₂₄H₃₄N₂O₃S
• Molecular Weight: 430.612

Synonyms:(-)-2-methylpropane-2-sulfonic acid [(1S,3S)-3-amino-4-benzyloxy-3-methyl-1-((E)-styryl)butyl]amide

Chemical Property of (-)-2-methylpropane-2-sulfonic acid [(1S,3S)-3-amino-4-benzyloxy-3-methyl-1-((E)-styryl)butyl]amide

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Technology Process of (-)-2-methylpropane-2-sulfonic acid [(1S,3S)-3-amino-4-benzyloxy-3-methyl-1-((E)-styryl)butyl]amide

There total 4 articles about (-)-2-methylpropane-2-sulfonic acid [(1S,3S)-3-amino-4-benzyloxy-3-methyl-1-((E)-styryl)butyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Methyl-propane-2-sulfonic acid [(1S,3S)-4-benzyloxy-3-methyl-3-((R)-2-methyl-propane-2-sulfinylamino)-1-((E)-styryl)-butyl]-amide → (-)-2-methylpropane-2-sulfonic acid [(1S,3S)-3-amino-4-benzyloxy-3-methyl-1-((E)-styryl)butyl]amide (873695-41-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 0 ℃; for 2h;

DOI:10.1021/ol0525258

Reference yield:

2-methylpropane-2-sulfonic acid (3-phenyl-(E)-allylidene)amide → (-)-2-methylpropane-2-sulfonic acid [(1S,3S)-3-amino-4-benzyloxy-3-methyl-1-((E)-styryl)butyl]amide (873695-41-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / LHDMS / tetrahydrofuran / -78 °C

2: 65 percent / tetrahydrofuran / 1 h / 0 °C

3: 99 percent / aq. HCl / methanol; dioxane / 2 h / 0 °C

With hydrogenchloride; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol;

DOI:10.1021/ol0525258

Reference yield:

(-)-2-methylpropane-2-sulfonic acid [(1S,3S)-4-benzyloxy-3-methyl-3-(2-(RS)-methylpropane-2-sulfinylamino)-1-((E)-styryl)butyl]amide → (-)-2-methylpropane-2-sulfonic acid [(1S,3S)-3-amino-4-benzyloxy-3-methyl-1-((E)-styryl)butyl]amide (873695-41-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / tetrahydrofuran / 1 h / 0 °C

2: 99 percent / aq. HCl / methanol; dioxane / 2 h / 0 °C

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; methanol;

DOI:10.1021/ol0525258

upstream raw materials:

(R_S)-N-(2-(1-benzyloxy)propylidene-2-methylpropane)sulfinamide

Downstream raw materials:

(-)-(4S,6S)-6-benzyloxymethyl-6-methyl-4-((E)-styryl)-1,4,5,6-tetrahydropyrimidine

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