Technology Process of [3-((R)-4-Aminomethyl-3-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-ylsulfanyl)-propyl]-dimethyl-amine
There total 16 articles about [3-((R)-4-Aminomethyl-3-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-ylsulfanyl)-propyl]-dimethyl-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydroxylamine; zinc;
Yield given. Multistep reaction;
2.) AcOH, RT, 30 min;
DOI:10.1021/ja00268a040
- Guidance literature:
-
Multi-step reaction with 9 steps
1: CH2Cl2 / Ambient temperature
2: BF3*O2Et / benzene / Heating
3: 85 percent / MPLC, HSiCl3, Et3N / benzene / Heating
4: 99 percent / MsCl, Et3N / CH2Cl2 / 0 °C
5: NaH / tetrahydrofuran / 0 - 20 °C
6: 58 percent / LAH / tetrahydrofuran / Ambient temperature
7: CrO3*(Pyr)2 / CH2Cl2 / Ambient temperature
8: HONH2, NaOAc / H2O; ethanol
9: Zn, HOAc, H2S / methanol
With
lithium aluminium tetrahydride; boron trifluoride diethyl etherate; trichlorosilane; hydrogen sulfide; hydroxylamine; sodium acetate; dipyridine chromium trioxide; sodium hydride; acetic acid; methanesulfonyl chloride; triethylamine; zinc;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; benzene;
DOI:10.1021/ja00317a054
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 99 percent / MsCl, Et3N / CH2Cl2 / 0 °C
2: NaH / tetrahydrofuran / 0 - 20 °C
3: 58 percent / LAH / tetrahydrofuran / Ambient temperature
4: CrO3*(Pyr)2 / CH2Cl2 / Ambient temperature
5: HONH2, NaOAc / H2O; ethanol
6: Zn, HOAc, H2S / methanol
With
lithium aluminium tetrahydride; hydrogen sulfide; hydroxylamine; sodium acetate; dipyridine chromium trioxide; sodium hydride; acetic acid; methanesulfonyl chloride; triethylamine; zinc;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1021/ja00317a054