[3-((R)-4-Aminomethyl-3-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-ylsulfanyl)-propyl]-dimethyl-amine

Base Information

Chemical Name:[3-((R)-4-Aminomethyl-3-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-ylsulfanyl)-propyl]-dimethyl-amine
CAS No.:101349-01-3
Molecular Formula:C₂₂H₃₁N₃OS
Molecular Weight:385.574
Hs Code.:

Synonyms:[3-((R)-4-Aminomethyl-3-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-ylsulfanyl)-propyl]-dimethyl-amine

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Chemical Property of [3-((R)-4-Aminomethyl-3-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-ylsulfanyl)-propyl]-dimethyl-amine

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Technology Process of [3-((R)-4-Aminomethyl-3-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-ylsulfanyl)-propyl]-dimethyl-amine

There total 16 articles about [3-((R)-4-Aminomethyl-3-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-ylsulfanyl)-propyl]-dimethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88889-13-8
(R)-3-Benzyloxy-5-(3-dimethylamino-propylsulfanyl)-5,6,7,8-tetrahydro-quinoline-4-carbaldehyde

: 101349-01-3
[3-((R)-4-Aminomethyl-3-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-ylsulfanyl)-propyl]-dimethyl-amine

Guidance literature:: With hydroxylamine; zinc; Yield given. Multistep reaction; 2.) AcOH, RT, 30 min;
DOI:10.1021/ja00268a040

Reference yield:

: 88889-11-6
3-(benzyloxy)-4-(ethoxycarbonyl)-5,6,7,8-tetrahydro-5-hydroxyquinoline

: 101349-01-3
[3-((R)-4-Aminomethyl-3-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-ylsulfanyl)-propyl]-dimethyl-amine

Guidance literature:: Multi-step reaction with 9 steps

1: CH₂Cl₂ / Ambient temperature

2: BF₃*O₂Et / benzene / Heating

3: 85 percent / MPLC, HSiCl₃, Et₃N / benzene / Heating

4: 99 percent / MsCl, Et₃N / CH₂Cl₂ / 0 °C

5: NaH / tetrahydrofuran / 0 - 20 °C

6: 58 percent / LAH / tetrahydrofuran / Ambient temperature

7: CrO₃*(Pyr)2 / CH₂Cl₂ / Ambient temperature

8: HONH₂, NaOAc / H₂O; ethanol

9: Zn, HOAc, H₂S / methanol

With lithium aluminium tetrahydride; boron trifluoride diethyl etherate; trichlorosilane; hydrogen sulfide; hydroxylamine; sodium acetate; dipyridine chromium trioxide; sodium hydride; acetic acid; methanesulfonyl chloride; triethylamine; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; benzene;
DOI:10.1021/ja00317a054

Reference yield:

: 88929-66-2
(S)-3-Benzyloxy-5-hydroxy-5,6,7,8-tetrahydro-quinoline-4-carboxylic acid ethyl ester

: 101349-01-3
[3-((R)-4-Aminomethyl-3-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-ylsulfanyl)-propyl]-dimethyl-amine

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / MsCl, Et₃N / CH₂Cl₂ / 0 °C

2: NaH / tetrahydrofuran / 0 - 20 °C

3: 58 percent / LAH / tetrahydrofuran / Ambient temperature

4: CrO₃*(Pyr)2 / CH₂Cl₂ / Ambient temperature

5: HONH₂, NaOAc / H₂O; ethanol

6: Zn, HOAc, H₂S / methanol

With lithium aluminium tetrahydride; hydrogen sulfide; hydroxylamine; sodium acetate; dipyridine chromium trioxide; sodium hydride; acetic acid; methanesulfonyl chloride; triethylamine; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1021/ja00317a054