Technology Process of benzyl (2R,3S,5S)-3-hydroxy-2-hydroxymethyl-5-(iodomethyl)pyrrolidine-1-carboxylate
There total 9 articles about benzyl (2R,3S,5S)-3-hydroxy-2-hydroxymethyl-5-(iodomethyl)pyrrolidine-1-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
iodine;
In
dichloromethane;
at 25 ℃;
for 1.5h;
Inert atmosphere;
DOI:10.1039/c3md00033h
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1.5 h / 0 - 25 °C / Inert atmosphere
2: boron trifluoride diethyl etherate / acetone / 15 h / 25 °C / Inert atmosphere
3: diethyl ether / 2 h / -78 °C / Inert atmosphere
4: zinc tetrahydridoborate*Et2O; cerium(III) chloride heptahydrate / methanol / 2.5 h / 0 - 25 °C / Inert atmosphere
5: water; acetic acid / 15 h / 50 °C
6: toluene-4-sulfonic acid / acetone / 1 h / 25 °C / Inert atmosphere
7: acetonitrile / 1 h / 90 °C / Inert atmosphere
8: sodium chloride / ethyl acetate; water; acetonitrile / 1.5 h / 25 °C
9: iodine / dichloromethane / 1.5 h / 25 °C / Inert atmosphere
With
4-methyl-morpholine; zinc tetrahydridoborate*Et2O; cerium(III) chloride heptahydrate; boron trifluoride diethyl etherate; water; iodine; toluene-4-sulfonic acid; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium chloride;
In
methanol; diethyl ether; dichloromethane; water; ethyl acetate; acetone; acetonitrile;
DOI:10.1039/c3md00033h
- Guidance literature:
-
Multi-step reaction with 8 steps
1: boron trifluoride diethyl etherate / acetone / 15 h / 25 °C / Inert atmosphere
2: diethyl ether / 2 h / -78 °C / Inert atmosphere
3: zinc tetrahydridoborate*Et2O; cerium(III) chloride heptahydrate / methanol / 2.5 h / 0 - 25 °C / Inert atmosphere
4: water; acetic acid / 15 h / 50 °C
5: toluene-4-sulfonic acid / acetone / 1 h / 25 °C / Inert atmosphere
6: acetonitrile / 1 h / 90 °C / Inert atmosphere
7: sodium chloride / ethyl acetate; water; acetonitrile / 1.5 h / 25 °C
8: iodine / dichloromethane / 1.5 h / 25 °C / Inert atmosphere
With
zinc tetrahydridoborate*Et2O; cerium(III) chloride heptahydrate; boron trifluoride diethyl etherate; water; iodine; toluene-4-sulfonic acid; acetic acid; sodium chloride;
In
methanol; diethyl ether; dichloromethane; water; ethyl acetate; acetone; acetonitrile;
DOI:10.1039/c3md00033h
