trandolapril benzyl ester

Base Information

• Chemical Name: trandolapril benzyl ester
• CAS No.: 98677-37-3
• Molecular Formula: C₃₁H₄₀N₂O₅
• Molecular Weight: 520.669
• Mol file: 98677-37-3.mol

Synonyms:trandolapril benzyl ester

Chemical Property of trandolapril benzyl ester

Chemical Property:

• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform, Dichloromethane, Dimethyl Sulfoxide, Ethyl Acetate

Purity/Quality:

TrandolaprilBenzylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Protected Trandolapril (T713500), an antihypertensive. Angiotensin converting enzyme (ACE) inhibitor.

Technology Process of trandolapril benzyl ester

There total 6 articles about trandolapril benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylmethyl-(2S,3aR,7aS)-octahydroindole-2-carboxylate hydrochloride (145641-35-6) + [1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine (82717-96-2,122076-80-6) → trandolapril benzyl ester (98677-37-3)

Guidance literature:

With N-ethylmorpholine;; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 - 25 ℃; for 4.5h;

Reference yield:

N-[(S)-1-carbethoxy-3-phenyl-propyl]-S-alaninoyl chloride hydrochloride (114192-42-6) + phenylmethyl-(2S,3aR,7aS)-octahydroindole-2-carboxylate hydrochloride (145641-35-6) → trandolapril benzyl ester (98677-37-3)

Guidance literature:

phenylmethyl-(2S,3aR,7aS)-octahydroindole-2-carboxylate hydrochloride; With triethylamine; In dichloromethane; at 25 - 30 ℃; for 0.416667 - 0.5h;

N-[(S)-1-carbethoxy-3-phenyl-propyl]-S-alaninoyl chloride hydrochloride; In dichloromethane; at 0 - 5 ℃; for 17 - 20h;

Reference yield:

(2S,3aR,7aS-octahydroindole)-2-carboxylic acid-benzyl ester (144540-71-6) + N-[1-(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanine hydrochloride (80828-26-8) → trandolapril benzyl ester (98677-37-3)

Guidance literature:

N-[1-(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanine hydrochloride; With hydrogenchloride; (chloromethylene)dimethyliminium chloride; In dichloromethane; at -10 ℃; for 0.666667h; Inert atmosphere;

(2S,3aR,7aS-octahydroindole)-2-carboxylic acid-benzyl ester; With sodium hydrogencarbonate; In dichloromethane; water;

upstream raw materials:

phenylmethyl-(2S,3aR,7aS)-octahydroindole-2-carboxylate hydrochloride

[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine

cis,syn-octahydro-1H-indole-2(S)-carboxylic acid, phenylmethylester

benzyl (2SR,3aRS,7aSR)-octahydro-1H-indole-2-carboxylate

Downstream raw materials:

trandolapril