methyl 2-(8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetate hydrochloride

Base Information

Chemical Name:methyl 2-(8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetate hydrochloride
CAS No.:866460-86-8
Molecular Formula:C₁₅H₁₇FN₂O₂*ClH
Molecular Weight:312.772
Hs Code.:
Mol file:866460-86-8.mol

Synonyms:Ethyl 2-(8-Fluoro-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)acetate hydrochloride

Suppliers and Price of methyl 2-(8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetate hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of methyl 2-(8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetate hydrochloride

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of methyl 2-(8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetate hydrochloride

There total 4 articles about methyl 2-(8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1060979-22-7
tert-butyl 5-(2-ethoxy-2-oxoethyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

: 866460-86-8
Ethyl 2-(8-Fluoro-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)acetate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jm400122f

Reference yield:

: 870471-42-4
8-fluoro-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carboxylic acid tert-butyl ester

: 866460-86-8
Ethyl 2-(8-Fluoro-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)acetate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / acetone / 20 °C

2: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C

With hydrogenchloride; caesium carbonate; In 1,4-dioxane; dichloromethane; acetone;
DOI:10.1021/jm400122f

Reference yield:

: 39876-39-6
8-fluoro-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole

: 866460-86-8
Ethyl 2-(8-Fluoro-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)acetate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

2: caesium carbonate / acetone / 20 °C

3: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C

With hydrogenchloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; acetone;
DOI:10.1021/jm400122f