4,4'-di(p-aminophenylethynyl)-6,6'-bis(N,N-bis(t-butoxycarbonylmethyl)aminomethyl)-2,2'-bipyridine

Base Information

Chemical Name:4,4'-di(p-aminophenylethynyl)-6,6'-bis(N,N-bis(t-butoxycarbonylmethyl)aminomethyl)-2,2'-bipyridine
CAS No.:1621462-38-1
Molecular Formula:C₅₂H₆₄N₆O₈
Molecular Weight:901.116
Hs Code.:

Synonyms:4,4'-di(p-aminophenylethynyl)-6,6'-bis(N,N-bis(t-butoxycarbonylmethyl)aminomethyl)-2,2'-bipyridine

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Chemical Property of 4,4'-di(p-aminophenylethynyl)-6,6'-bis(N,N-bis(t-butoxycarbonylmethyl)aminomethyl)-2,2'-bipyridine

Chemical Property:

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Technology Process of 4,4'-di(p-aminophenylethynyl)-6,6'-bis(N,N-bis(t-butoxycarbonylmethyl)aminomethyl)-2,2'-bipyridine

There total 4 articles about 4,4'-di(p-aminophenylethynyl)-6,6'-bis(N,N-bis(t-butoxycarbonylmethyl)aminomethyl)-2,2'-bipyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 14235-81-5
4-Ethynylaniline

: 144342-81-4
Tetra(tert-butyl) 2,2',2,2'-<(4,4'-dibromo-2,2'-bipyridine-6,6'-diyl)bis(methylenenitrilo)>tetrakis(acetate)

: 1621462-38-1
4,4'-di(p-aminophenylethynyl)-6,6'-bis(N,N-bis(t-butoxycarbonylmethyl)aminomethyl)-2,2'-bipyridine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 50 - 52 ℃; for 24h; Inert atmosphere;
DOI:10.14233/ajchem.2014.15686

Reference yield:

: 143359-62-0
(4,4'-dinitro-2,2'-bipyridine-6,6'-diyl)di(methylene) bis(trifluoroacetate)

: 1621462-38-1
4,4'-di(p-aminophenylethynyl)-6,6'-bis(N,N-bis(t-butoxycarbonylmethyl)aminomethyl)-2,2'-bipyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran; water / 0.08 h / 20 °C

1.2: 20 h

2.1: acetic acid; hydrogen bromide / 5 h / 101 °C

3.1: sodium carbonate / acetonitrile / 24 h / 80 °C

4.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 24 h / 50 - 52 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen bromide; sodium carbonate; acetic acid; triethylamine; In tetrahydrofuran; water; acetonitrile;
DOI:10.14233/ajchem.2014.15686

Reference yield:

: 143359-64-2
4,4'-dinitro-2,2'-bipyridine-6,6'-dimethanol

: 1621462-38-1
4,4'-di(p-aminophenylethynyl)-6,6'-bis(N,N-bis(t-butoxycarbonylmethyl)aminomethyl)-2,2'-bipyridine

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; hydrogen bromide / 5 h / 101 °C

2: sodium carbonate / acetonitrile / 24 h / 80 °C

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 24 h / 50 - 52 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen bromide; sodium carbonate; acetic acid; triethylamine; In tetrahydrofuran; acetonitrile;
DOI:10.14233/ajchem.2014.15686