Thioacetic acid S-[(2R,3R,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

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Chemical Name:Thioacetic acid S-[(2R,3R,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester
CAS No.:156737-23-4
Molecular Formula:C₃₃H₃₄N₂O₇S
Molecular Weight:602.708
Hs Code.:

Thioacetic acid S-[(2R,3R,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

Synonyms:Thioacetic acid S-[(2R,3R,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

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Chemical Property of Thioacetic acid S-[(2R,3R,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

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Technology Process of Thioacetic acid S-[(2R,3R,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

There total 1 articles about Thioacetic acid S-[(2R,3R,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114551-15-4
5'-O-(4,4'-dimethoxytrityl)-1-(3-deoxy-β-D-arabinofuranosyl)thymine

: 10387-40-3
potassium thioacetate

: 156737-23-4
Thioacetic acid S-[(2R,3R,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

Guidance literature:: With methanesulfonyl chloride; Yield given. Multistep reaction; 1.) Pyr, room t.; 2.) DMF, 80 degC;
DOI:10.1016/S0040-4039(00)78530-3

Reference yield: 95.0%

: 156737-23-4
Thioacetic acid S-[(2R,3R,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

: 156737-24-5
1-{(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-mercapto-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With ammonia; In methanol; Ambient temperature;
DOI:10.1016/S0040-4039(00)78530-3

Reference yield:

: 156737-23-4
Thioacetic acid S-[(2R,3R,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

: 170563-43-6
C₄₂H₄₆N₄O₁₁S

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / NH₃ / methanol / Ambient temperature

2: 65 percent / DiPEA / CH₂Cl₂ / 0 °C

3: 70 percent / MeONa / methanol / Ambient temperature

With ammonia; sodium methylate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(00)78530-3