Cyclohexanol,2,2-difluoro-3-methyl-,(1R-trans)-(9CI)

Base Information

Chemical Name:Cyclohexanol,2,2-difluoro-3-methyl-,(1R-trans)-(9CI)
CAS No.:156484-00-3
Molecular Formula:C₇H₁₂F₂O
Molecular Weight:150.168
Hs Code.:
Mol file:156484-00-3.mol

Synonyms:Cyclohexanol,2,2-difluoro-3-methyl-,(1R-trans)-(9CI)

Suppliers and Price of Cyclohexanol,2,2-difluoro-3-methyl-,(1R-trans)-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of Cyclohexanol,2,2-difluoro-3-methyl-,(1R-trans)-(9CI)

Chemical Property:

PSA：20.23000
LogP:1.80260

Purity/Quality:: 99%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of Cyclohexanol,2,2-difluoro-3-methyl-,(1R-trans)-(9CI)

There total 7 articles about Cyclohexanol,2,2-difluoro-3-methyl-,(1R-trans)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 156483-99-7
(1R,3R)-2,2-Difluoro-3-methyl-cyclohexyl benzoate

: 156484-00-3
(1R,3R)-2,2-Difluoro-3-methyl-cyclohexanol

Guidance literature:: With potassium hydroxide; In methanol; for 1h; Ambient temperature;
DOI:10.1021/jo00091a041

Reference yield:

: 156558-20-2
(2R,3R,R_S)-1-chloro-1,1-difluoro-3-<(4-methylphenyl)sulphinyl>hept-6-en-2-ol

: 156484-00-3
(1R,3R)-2,2-Difluoro-3-methyl-cyclohexanol

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / trifluoroacetic anhydride, NaI / acetone / 0.17 h / -40 °C

2: 60 percent / AIBN, tributyltin hydride / benzene / 70 °C

3: 79 percent / 4-(dimethylamino)pyridine, dicyclohexylcarbodiimide / CH₂Cl₂ / 1 h / Ambient temperature

4: 87 percent / W-2 Raney-Ni / ethanol / 0.17 h / 80 °C

5: 99 percent / 1percent aq. KOH / methanol / 1 h / Ambient temperature

With dmap; potassium hydroxide; 2,2'-azobis(isobutyronitrile); W-2 Raney-Ni; tri-n-butyl-tin hydride; dicyclohexyl-carbodiimide; trifluoroacetic anhydride; sodium iodide; In methanol; ethanol; dichloromethane; acetone; benzene;
DOI:10.1021/jo00091a041

Reference yield:

: 136310-09-3,136310-10-6
(3RS,R_S)-1-Chloro-1,1-difluoro-3-<(4-methylphenyl)sulfinyl>hept-6-en-2-one

: 156484-00-3
(1R,3R)-2,2-Difluoro-3-methyl-cyclohexanol

Guidance literature:: Multi-step reaction with 6 steps

1: 14.6 percent / sodium borohydride, 30percent aq. ammonia / methanol / 0.17 h / 20 °C

2: 96 percent / trifluoroacetic anhydride, NaI / acetone / 0.17 h / -40 °C

3: 60 percent / AIBN, tributyltin hydride / benzene / 70 °C

4: 79 percent / 4-(dimethylamino)pyridine, dicyclohexylcarbodiimide / CH₂Cl₂ / 1 h / Ambient temperature

5: 87 percent / W-2 Raney-Ni / ethanol / 0.17 h / 80 °C

6: 99 percent / 1percent aq. KOH / methanol / 1 h / Ambient temperature

With dmap; potassium hydroxide; ammonium hydroxide; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); W-2 Raney-Ni; tri-n-butyl-tin hydride; dicyclohexyl-carbodiimide; trifluoroacetic anhydride; sodium iodide; In methanol; ethanol; dichloromethane; acetone; benzene;
DOI:10.1021/jo00091a041