β-(2-methylphenyl)benzenepropanol

Base Information

• Chemical Name: β-(2-methylphenyl)benzenepropanol
• CAS No.: 53423-44-2
• Molecular Formula: C₁₆H₁₈O
• Molecular Weight: 226.318
• Mol file: 53423-44-2.mol

Synonyms:β-(2-methylphenyl)benzenepropanol

Chemical Property of β-(2-methylphenyl)benzenepropanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of β-(2-methylphenyl)benzenepropanol

There total 7 articles about β-(2-methylphenyl)benzenepropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-o-tolylethanol (19819-98-8) + benzyl alcohol (100-51-6,185532-71-2) → β-(2-methylphenyl)benzenepropanol (53423-44-2)

Guidance literature:

With tris(triphenylphosphine)ruthenium(II) chloride; potassium tert-butylate; In toluene; at 120 ℃; for 24h;

DOI:10.1021/acs.joc.8b01558

Reference yield: 70.0%

α-(2-methylphenyl)benzenepropionic acid (180624-80-0) → β-(2-methylphenyl)benzenepropanol (53423-44-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jo960567r

Reference yield:

o-methylphenylacetic acid (644-36-0) → β-(2-methylphenyl)benzenepropanol (53423-44-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) nBuLi / 1.) THF, hexane, -78 deg C, 35 min, 2.) -78 deg C -> room temperature, 3 h; room temperature, overnight

2: 70 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

With lithium aluminium tetrahydride; n-butyllithium; In tetrahydrofuran;

DOI:10.1021/jo960567r

upstream raw materials:

Ethyl-3-phenyl-2-(o-tolyl)-propionat

α-(2-methylphenyl)benzenepropionic acid

o-methylphenylacetic acid

benzyl bromide

Downstream raw materials:

4-Benzyl-5-methyl-isochroman-1-one

4-Benzyl-5-methyl-isochroman

{3-[(2-methoxyethoxy)methoxy]-2-(2-methylphenyl)propyl}benzene