2-sec-Butyl-4-(3-carboxy-4-methyl-1-phenethyl-hexyldisulfanyl)-6-phenyl-hexanoic acid

Base Information

Chemical Name:2-sec-Butyl-4-(3-carboxy-4-methyl-1-phenethyl-hexyldisulfanyl)-6-phenyl-hexanoic acid
CAS No.:159010-35-2
Molecular Formula:C₃₂H₄₆O₄S₂
Molecular Weight:558.847
Hs Code.:

Synonyms:2-sec-Butyl-4-(3-carboxy-4-methyl-1-phenethyl-hexyldisulfanyl)-6-phenyl-hexanoic acid

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Chemical Property of 2-sec-Butyl-4-(3-carboxy-4-methyl-1-phenethyl-hexyldisulfanyl)-6-phenyl-hexanoic acid

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Technology Process of 2-sec-Butyl-4-(3-carboxy-4-methyl-1-phenethyl-hexyldisulfanyl)-6-phenyl-hexanoic acid

There total 9 articles about 2-sec-Butyl-4-(3-carboxy-4-methyl-1-phenethyl-hexyldisulfanyl)-6-phenyl-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 159010-30-7
3-sec-Butyl-5-phenethyl-dihydro-thiophen-2-one

: 159010-35-2
2-sec-Butyl-4-(3-carboxy-4-methyl-1-phenethyl-hexyldisulfanyl)-6-phenyl-hexanoic acid

Guidance literature:: With sodium hydroxide; oxygen; In ethanol; for 24h; Ambient temperature;
DOI:10.1021/jm00038a016

Reference yield:

: 121842-76-0
(R)-2-bromo-4-phenylbutyric acid

: 159010-35-2
2-sec-Butyl-4-(3-carboxy-4-methyl-1-phenethyl-hexyldisulfanyl)-6-phenyl-hexanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) KOH / 1.) DMF, 2.) DMF, RT, overnight

2: SOCl₂ / 1.) RT, 1 h, 2.) 80 deg C, 40 min

3: NaBH₄, LiCl / tetrahydrofuran; ethanol / Ambient temperature

4: NaI, chlorotrimethylsilane / acetonitrile / 1.5 h

5: 1.) NaH / 1.) 1,2-dimethoxyethane, 0 deg C, 10 min, 2.) 1,2-dimethoxyethane, RT, 40 h

6: 1.) NaH / 1.) 1,2-dimethoxyethane, 0 deg C, 15 min, 2.) 1,2-dimethoxyethane, RT, 18 h

7: 70 percent / 20percent KOH / dimethylsulfoxide / 1.5 h / 60 - 70 °C

8: 51 percent / trifluoroacetic acid / 1 h / 90 °C

9: 47 percent / 4 N NaOH, O₂ / ethanol / 24 h / Ambient temperature

With potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; chloro-trimethyl-silane; thionyl chloride; oxygen; sodium hydride; trifluoroacetic acid; sodium iodide; lithium chloride; In tetrahydrofuran; ethanol; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm00038a016

Reference yield:

: 2-(4-Methoxy-benzylsulfanyl)-4-phenyl-butan-1-ol

: 159010-35-2
2-sec-Butyl-4-(3-carboxy-4-methyl-1-phenethyl-hexyldisulfanyl)-6-phenyl-hexanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: NaI, chlorotrimethylsilane / acetonitrile / 1.5 h

2: 1.) NaH / 1.) 1,2-dimethoxyethane, 0 deg C, 10 min, 2.) 1,2-dimethoxyethane, RT, 40 h

3: 1.) NaH / 1.) 1,2-dimethoxyethane, 0 deg C, 15 min, 2.) 1,2-dimethoxyethane, RT, 18 h

4: 70 percent / 20percent KOH / dimethylsulfoxide / 1.5 h / 60 - 70 °C

5: 51 percent / trifluoroacetic acid / 1 h / 90 °C

6: 47 percent / 4 N NaOH, O₂ / ethanol / 24 h / Ambient temperature

With potassium hydroxide; sodium hydroxide; chloro-trimethyl-silane; oxygen; sodium hydride; trifluoroacetic acid; sodium iodide; In ethanol; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm00038a016