1,1-dimethylethyl [3-({[4-bromo-5-(1-methyl-1H-pyrazol-5-yl)-2-thienyl]carbonyl}amino)-4-phenylbutyl]carbamate

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Chemical Name:1,1-dimethylethyl [3-({[4-bromo-5-(1-methyl-1H-pyrazol-5-yl)-2-thienyl]carbonyl}amino)-4-phenylbutyl]carbamate
CAS No.:1047644-96-1
Molecular Formula:C₂₄H₂₉BrN₄O₃S
Molecular Weight:533.489
Hs Code.:

Synonyms:1,1-dimethylethyl [3-({[4-bromo-5-(1-methyl-1H-pyrazol-5-yl)-2-thienyl]carbonyl}amino)-4-phenylbutyl]carbamate

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Chemical Property of 1,1-dimethylethyl [3-({[4-bromo-5-(1-methyl-1H-pyrazol-5-yl)-2-thienyl]carbonyl}amino)-4-phenylbutyl]carbamate

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Technology Process of 1,1-dimethylethyl [3-({[4-bromo-5-(1-methyl-1H-pyrazol-5-yl)-2-thienyl]carbonyl}amino)-4-phenylbutyl]carbamate

There total 6 articles about 1,1-dimethylethyl [3-({[4-bromo-5-(1-methyl-1H-pyrazol-5-yl)-2-thienyl]carbonyl}amino)-4-phenylbutyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 909913-73-1
1,1-dimethylethyl (3-amino-4-phenylbutyl)carbamate

: 1047629-23-1
4-bromo-5-(1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxylic acid

: 1047644-96-1
1,1-dimethylethyl [3-({[4-bromo-5-(1-methyl-1H-pyrazol-5-yl)-2-thienyl]carbonyl}amino)-4-phenylbutyl]carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; at 25 ℃; for 16h;

Reference yield:

: 19212-27-2
3-oxo-4-phenylbutyronitrile

: 1047644-96-1
1,1-dimethylethyl [3-({[4-bromo-5-(1-methyl-1H-pyrazol-5-yl)-2-thienyl]carbonyl}amino)-4-phenylbutyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 °C

2: tetrahydrofuran / 0.5 h

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 20 °C

4: hydrazine / tetrahydrofuran; methanol / 12 h / 50 °C

5: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 16 h / 25 °C

With lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; hydrazine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 6324-10-3
4,5-Dibromo-thiophene-2-carboxylic acid

: 1047644-96-1
1,1-dimethylethyl [3-({[4-bromo-5-(1-methyl-1H-pyrazol-5-yl)-2-thienyl]carbonyl}amino)-4-phenylbutyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / 80 °C

2: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 16 h / 25 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water;