(3R,4R,6S)-3-(3,3-Diethoxy-propyl)-4-isopropenyl-1,3-dimethyl-6-prop-2-ynyloxy-2-vinyl-cyclohexene

Base Information

Chemical Name:(3R,4R,6S)-3-(3,3-Diethoxy-propyl)-4-isopropenyl-1,3-dimethyl-6-prop-2-ynyloxy-2-vinyl-cyclohexene
CAS No.:225653-31-6
Molecular Formula:C₂₃H₃₆O₃
Molecular Weight:360.537
Hs Code.:

Synonyms:(3R,4R,6S)-3-(3,3-Diethoxy-propyl)-4-isopropenyl-1,3-dimethyl-6-prop-2-ynyloxy-2-vinyl-cyclohexene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4R,6S)-3-(3,3-Diethoxy-propyl)-4-isopropenyl-1,3-dimethyl-6-prop-2-ynyloxy-2-vinyl-cyclohexene

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Technology Process of (3R,4R,6S)-3-(3,3-Diethoxy-propyl)-4-isopropenyl-1,3-dimethyl-6-prop-2-ynyloxy-2-vinyl-cyclohexene

There total 9 articles about (3R,4R,6S)-3-(3,3-Diethoxy-propyl)-4-isopropenyl-1,3-dimethyl-6-prop-2-ynyloxy-2-vinyl-cyclohexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 106-96-7
propargyl bromide

: 225653-30-5
(1S,4R,5R)-4-(3,3-Diethoxy-propyl)-5-isopropenyl-2,4-dimethyl-3-vinyl-cyclohex-2-enol

: 225653-31-6
(3R,4R,6S)-3-(3,3-Diethoxy-propyl)-4-isopropenyl-1,3-dimethyl-6-prop-2-ynyloxy-2-vinyl-cyclohexene

Guidance literature:: With sodium hydroxide; tetra-(n-butyl)ammonium iodide; In water; Ambient temperature;
DOI:10.1039/a900081j

Reference yield:

: 2244-16-8,6485-40-1
(S)-p-mentha-6,8-dien-2-one

: 225653-31-6
(3R,4R,6S)-3-(3,3-Diethoxy-propyl)-4-isopropenyl-1,3-dimethyl-6-prop-2-ynyloxy-2-vinyl-cyclohexene

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) LDA / 1.) THF, -10 deg C, 2.) THF

2: 1.) LDA / 1.) THF, HMPA, -78 deg C, 2.) THF, HMPA

3: 92 percent / H₂O₂, NaOH / methanol / Ambient temperature

4: tetrahydrofuran / -78 °C

5: NaH / dimethylformamide / 0 - 20 °C

6: silica gel, H₂O

7: 85 percent / tetrahydrofuran / -20 °C

8: 97 percent / Bu₄NI, NaOH / H₂O / Ambient temperature

With sodium hydroxide; water; dihydrogen peroxide; silica gel; tetra-(n-butyl)ammonium iodide; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1039/a900081j

Reference yield:

: 58871-25-3
3-iodopropionaldehyde diethyl acetal

: 225653-31-6
(3R,4R,6S)-3-(3,3-Diethoxy-propyl)-4-isopropenyl-1,3-dimethyl-6-prop-2-ynyloxy-2-vinyl-cyclohexene

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) LDA / 1.) THF, HMPA, -78 deg C, 2.) THF, HMPA

2: 92 percent / H₂O₂, NaOH / methanol / Ambient temperature

3: tetrahydrofuran / -78 °C

4: NaH / dimethylformamide / 0 - 20 °C

5: silica gel, H₂O

6: 85 percent / tetrahydrofuran / -20 °C

7: 97 percent / Bu₄NI, NaOH / H₂O / Ambient temperature

With sodium hydroxide; water; dihydrogen peroxide; silica gel; tetra-(n-butyl)ammonium iodide; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1039/a900081j