5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}-1'-deoxy-1'-(2,4-difluorotoluene)-β-D-ribofuranose

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}-1'-deoxy-1'-(2,4-difluorotoluene)-β-D-ribofuranose
• CAS No.: 1093268-42-8
• Molecular Formula: C₄₃H₅₄F₂O₇Si
• Molecular Weight: 748.98
• Mol file: 1093268-42-8.mol

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}-1'-deoxy-1'-(2,4-difluorotoluene)-β-D-ribofuranose

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}-1'-deoxy-1'-(2,4-difluorotoluene)-β-D-ribofuranose

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}-1'-deoxy-1'-(2,4-difluorotoluene)-β-D-ribofuranose

There total 1 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}-1'-deoxy-1'-(2,4-difluorotoluene)-β-D-ribofuranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

C33H32F2O6 (875302-29-7) + chloromethoxy-triisopropyl-silane (217300-17-9) → 5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}-1'-deoxy-1'-(2,4-difluorotoluene)-β-D-ribofuranose (1093268-42-8) + C43H54F2O7Si (1093268-45-1)

Guidance literature:

C₃₃H₃₂F₂O₆; With di-tert-butyltin dichloride; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 70 ℃; for 0.25h; Inert atmosphere;

chloromethoxy-triisopropyl-silane; In 1,2-dichloro-ethane; at 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/ja806716s

Reference yield: 84.0%

5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}-1'-deoxy-1'-(2,4-difluorotoluene)-β-D-ribofuranose (1093268-42-8) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → 5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}-1'-deoxy-1'-(2,4-difluorotoluene)-β-D-ribofuranose 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite) (1093268-44-0)

Guidance literature:

With N,N-dimethyl-ethanamine; In dichloromethane; at 20 ℃; for 2.5h; Inert atmosphere;

DOI:10.1021/ja806716s

upstream raw materials:

C₃₃H₃₂F₂O₆

chloromethoxy-triisopropyl-silane

Downstream raw materials:

5'-O-(4,4'-dimethoxytrityl)-2'-O-{[(triisopropylsilyl)oxy]methyl}-1'-deoxy-1'-(2,4-difluorotoluene)-β-D-ribofuranose 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)