4-((9-fluorenylmethoxy)carboxamido)phenylacetic acid N-hydroxysuccinimidate

Base Information

• Chemical Name: 4-((9-fluorenylmethoxy)carboxamido)phenylacetic acid N-hydroxysuccinimidate
• CAS No.: 147227-80-3
• Molecular Formula: C₂₇H₂₂N₂O₆
• Molecular Weight: 470.481
• Mol file: 147227-80-3.mol

Synonyms:4-((9-fluorenylmethoxy)carboxamido)phenylacetic acid N-hydroxysuccinimidate

Chemical Property of 4-((9-fluorenylmethoxy)carboxamido)phenylacetic acid N-hydroxysuccinimidate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-((9-fluorenylmethoxy)carboxamido)phenylacetic acid N-hydroxysuccinimidate

There total 1 articles about 4-((9-fluorenylmethoxy)carboxamido)phenylacetic acid N-hydroxysuccinimidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

di(succinimido) carbonate (74124-79-1) + Sodium; [4-(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl]-acetate → 4-((9-fluorenylmethoxy)carboxamido)phenylacetic acid N-hydroxysuccinimidate (147227-80-3)

Guidance literature:

In N,N-dimethyl-formamide; at 0 ℃; for 1h;

DOI:10.1021/jm00059a018

Reference yield:

4-((9-fluorenylmethoxy)carboxamido)phenylacetic acid N-hydroxysuccinimidate (147227-80-3) → N-(4-aminophenylacetyl)doxorubicin

Guidance literature:

Multi-step reaction with 2 steps

1: (i-Pr)2EtN / dimethylformamide / 18 h

2: morpholine / dimethylformamide / 3 h

With morpholine; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm00059a018

upstream raw materials:

di(succinimido) carbonate