Acetic acid (2R,3S,4S,5R,6R)-5-acetoxy-6-acetoxymethyl-2-[(2R,3S,4S,5R,6S)-6-acetoxymethyl-4,5-bis-benzyloxy-2-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-3-yloxy]-4-carbamoyloxy-tetrahydro-pyran-3-yl ester

Base Information

Chemical Name:Acetic acid (2R,3S,4S,5R,6R)-5-acetoxy-6-acetoxymethyl-2-[(2R,3S,4S,5R,6S)-6-acetoxymethyl-4,5-bis-benzyloxy-2-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-3-yloxy]-4-carbamoyloxy-tetrahydro-pyran-3-yl ester
CAS No.:217180-23-9
Molecular Formula:C₃₇H₄₃Cl₃N₂O₁₆
Molecular Weight:878.111
Hs Code.:

Acetic acid (2R,3S,4S,5R,6R)-5-acetoxy-6-acetoxymethyl-2-[(2R,3S,4S,5R,6S)-6-acetoxymethyl-4,5-bis-benzyloxy-2-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-3-yloxy]-4-carbamoyloxy-tetrahydro-pyran-3-yl ester

Synonyms:Acetic acid (2R,3S,4S,5R,6R)-5-acetoxy-6-acetoxymethyl-2-[(2R,3S,4S,5R,6S)-6-acetoxymethyl-4,5-bis-benzyloxy-2-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-3-yloxy]-4-carbamoyloxy-tetrahydro-pyran-3-yl ester

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Chemical Property of Acetic acid (2R,3S,4S,5R,6R)-5-acetoxy-6-acetoxymethyl-2-[(2R,3S,4S,5R,6S)-6-acetoxymethyl-4,5-bis-benzyloxy-2-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-3-yloxy]-4-carbamoyloxy-tetrahydro-pyran-3-yl ester

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Technology Process of Acetic acid (2R,3S,4S,5R,6R)-5-acetoxy-6-acetoxymethyl-2-[(2R,3S,4S,5R,6S)-6-acetoxymethyl-4,5-bis-benzyloxy-2-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-3-yloxy]-4-carbamoyloxy-tetrahydro-pyran-3-yl ester

There total 5 articles about Acetic acid (2R,3S,4S,5R,6R)-5-acetoxy-6-acetoxymethyl-2-[(2R,3S,4S,5R,6S)-6-acetoxymethyl-4,5-bis-benzyloxy-2-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-3-yloxy]-4-carbamoyloxy-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 545-06-2
trichloroacetonitrile

: 217180-22-8
6-O-acetyl-3,4-di-O-benzyl-2-O-(2,4,6-tri-O-acetyl-3-O-carbamoyl-α-D-mannopyranosyl)-α/β-gulopyranoside

: 217180-23-9
Acetic acid (2R,3S,4S,5R,6R)-5-acetoxy-6-acetoxymethyl-2-[(2R,3S,4S,5R,6S)-6-acetoxymethyl-4,5-bis-benzyloxy-2-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-3-yloxy]-4-carbamoyloxy-tetrahydro-pyran-3-yl ester

Guidance literature:: With potassium carbonate; In dichloromethane; for 6h;
DOI:10.1021/ja9819458

Reference yield:

: 102871-16-9,102871-17-0
1,6-di-O-acetyl-3,4-di-O-benzyl-2-O-(2,4,6-tri-O-acetyl-3-O-carbamoyl-α-D-mannopyranosyl)-L-gulopyranose

: 217180-23-9
Acetic acid (2R,3S,4S,5R,6R)-5-acetoxy-6-acetoxymethyl-2-[(2R,3S,4S,5R,6S)-6-acetoxymethyl-4,5-bis-benzyloxy-2-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-3-yloxy]-4-carbamoyloxy-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / C₆H₅CH₂NH₂ / 25 °C

2: 97 percent / K₂CO₃ / CH₂Cl₂ / 6 h

With potassium carbonate; benzylamine; In dichloromethane;
DOI:10.1021/ja9819458

Reference yield:

: 162112-03-0
2,4,6-tri-O-acetyl-3-O-carbamoyl-α-D-mannopyranoside

: 217180-23-9
Acetic acid (2R,3S,4S,5R,6R)-5-acetoxy-6-acetoxymethyl-2-[(2R,3S,4S,5R,6S)-6-acetoxymethyl-4,5-bis-benzyloxy-2-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-3-yloxy]-4-carbamoyloxy-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / K₂CO₃

2: 86 percent / BF₃*OEt₂ / CH₂Cl₂

3: 72 percent / C₆H₅CH₂NH₂ / 25 °C

4: 97 percent / K₂CO₃ / CH₂Cl₂ / 6 h

With boron trifluoride diethyl etherate; potassium carbonate; benzylamine; In dichloromethane;
DOI:10.1021/ja9819458