GLPG 0492

Base Information

Chemical Name:GLPG 0492
CAS No.:1215085-92-9
Molecular Formula:C₁₉H₁₄F₃N₃O₃
Molecular Weight:389.334
Hs Code.:

Synonyms:GLPG₀₄₉₂

Suppliers and Price of GLPG 0492

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
GLPG-0492
2.5mg
$ 425.00

TRC
GLPG-0492
25mg
$ 2360.00

Crysdot
GLPG0492 98+%
100mg
$ 1459.00

Crysdot
GLPG0492 98+%
50mg
$ 1042.00

Crysdot
GLPG0492 98+%
5mg
$ 243.00

Crysdot
GLPG0492 98+%
10mg
$ 347.00

Cayman Chemical
GLPG0492
1mg
$ 315.00

AK Scientific
4-[(4S)-4-(Hydroxymethyl)-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
1mg
$ 525.00

Total 21 raw suppliers

Chemical Property of GLPG 0492

Chemical Property:

Melting Point:66 - 71°C
Boiling Point:544.0±60.0 °C(Predicted)
PKA:13.50±0.10(Predicted)
Density:1.50±0.1 g/cm3(Predicted)
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:DMSO (Slightly), Ethanol (Slightly, Sonicated)

Purity/Quality:

99%, ^*data from raw suppliers

GLPG-0492 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description GLPG0492 is a selective androgen receptor modulator (SARM). It activates the androgen receptor in a transactivation assay (EC50 = 12 nM in HeLa cells expressing the human receptor). GLPG0492 (10 mg/kg per day) increases levator ani muscle weight, a marker of anabolic activity, but has no effect on ventral prostate weight, a marker of androgenic activity, in castrated rats. It increases twitch tension in isolated diaphragm strips, as well as increases the total distance run in a treadmill test and decreases gastrocnemius muscle fibrosis in the exercised-mdx mouse model of muscular dystrophy when administered at a dose of 30 mg/kg. GLPG0492 also reverses immobilization-induced muscle atrophy in a mouse model of hindlimb immobilization.
Uses GLPG-0492 is a non-steroidal Selective Androgen Receptor Modulator (SARM), which can be used to reduce muscle loss while sparing reproductive tissues.

Technology Process of GLPG 0492

There total 7 articles about GLPG 0492 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1401226-62-7
(S)-(-)-4-[2,5-dioxo-4-(hydroxymethyl)-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

: 77-78-1
dimethyl sulfate

: 1215085-92-9
GLPG₀₄₉₂

Guidance literature:: With potassium carbonate; In N,N-dimethyl acetamide; at 20 ℃; for 15h; Inert atmosphere;
DOI:10.1021/jm300281x

Reference yield: 48.0%

: 1215085-63-4
4-[2,5-dioxo-4-(hydroxymethyl)-3-methyl-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

: 1215085-93-0
(R)-(+)-4-[2,5-dioxo-4-(hydroxymethyl)-3-methyl-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

: 1215085-92-9
GLPG₀₄₉₂

Guidance literature:: With Chiralcel OD; In n-heptane; isopropyl alcohol; Resolution of racemate;
DOI:10.1021/jm300281x

Reference yield:

: 1215085-65-6
5-phenyl-5-(2-propenyloxy)methylimidazolidine-2,4-dione

: 1215085-93-0
(R)-(+)-4-[2,5-dioxo-4-(hydroxymethyl)-3-methyl-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

: 1215085-92-9
GLPG₀₄₉₂

Guidance literature:: Multi-step reaction with 4 steps

1: copper(I) oxide / N,N-dimethyl acetamide / 3 h / 160 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

3: boron dimethyl-trifluoro sulphide / dichloromethane / 4 h / 20 °C / Inert atmosphere

4: Chiralcel OD / n-heptane; isopropyl alcohol / Resolution of racemate

With copper(I) oxide; boron dimethyl-trifluoro sulphide; potassium carbonate; In n-heptane; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm300281x