<2(4S,5R)>-2-<4-<(4-Methoxyphenyl)methoxy>-5-methyl-3-methylene-6-phenylhexyl>-1,3-dioxolane

Base Information

Chemical Name:<2(4S,5R)>-2-<4-<(4-Methoxyphenyl)methoxy>-5-methyl-3-methylene-6-phenylhexyl>-1,3-dioxolane
CAS No.:164118-43-8
Molecular Formula:C₂₅H₃₂O₄
Molecular Weight:396.527
Hs Code.:

Synonyms:<2(4S,5R)>-2-<4-<(4-Methoxyphenyl)methoxy>-5-methyl-3-methylene-6-phenylhexyl>-1,3-dioxolane

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Chemical Property of <2(4S,5R)>-2-<4-<(4-Methoxyphenyl)methoxy>-5-methyl-3-methylene-6-phenylhexyl>-1,3-dioxolane

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Technology Process of <2(4S,5R)>-2-<4-<(4-Methoxyphenyl)methoxy>-5-methyl-3-methylene-6-phenylhexyl>-1,3-dioxolane

There total 9 articles about <2(4S,5R)>-2-<4-<(4-Methoxyphenyl)methoxy>-5-methyl-3-methylene-6-phenylhexyl>-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 2-<4-<(4-Methoxyphenyl)methoxy>-5-methyl-3-oxo-6-phenylhexyl>-1,3-dioxolane

: 164118-43-8
<2(4S,5R)>-2-<4-<(4-Methoxyphenyl)methoxy>-5-methyl-3-methylene-6-phenylhexyl>-1,3-dioxolane

Guidance literature:: In tetrahydrofuran; toluene; at 22 ℃; for 1h;

Reference yield:

: 78571-81-0,81096-89-1,85531-71-1,99883-80-4,116949-62-3,128575-26-8
2-Hydroxymethyl-3-phenylmethyloxirane

: 164118-43-8
<2(4S,5R)>-2-<4-<(4-Methoxyphenyl)methoxy>-5-methyl-3-methylene-6-phenylhexyl>-1,3-dioxolane

Guidance literature:: Multi-step reaction with 8 steps

1: 73 percent / NaH, Bu₄NI / tetrahydrofuran / 0.5 h / Heating

2: 89 percent / BuLi / toluene / 24 h / -20 °C

3: 53 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, molecular sieves (4 Angstroem) / CH₂Cl₂ / 4 h / 22 °C

4: 81 percent / iBu₂AlH / CH₂Cl₂ / 2 h / -78 °C

5: 98 percent / (COCl)2, DMSO, Et₃N / CH₂Cl₂ / 2 h / -78 °C

6: 1.) Mg / 2.) THF, 22 deg C, 6 h

7: 92 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.33 h / 22 °C

8: 1.) Cp₂TiCl₂ / 2.) THF, 22 deg C, 1 h

With bis(cyclopentadienyl)titanium dichloride; n-butyllithium; oxalyl dichloride; 4 A molecular sieve; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; Dess-Martin periodane; magnesium; dimethyl sulfoxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 164118-36-9
(2R,3S)-2-<<(4-Methoxyphenyl)methoxy>methyl>-3-phenylmethyloxirane

: 164118-43-8
<2(4S,5R)>-2-<4-<(4-Methoxyphenyl)methoxy>-5-methyl-3-methylene-6-phenylhexyl>-1,3-dioxolane

Guidance literature:: Multi-step reaction with 7 steps

1: 89 percent / BuLi / toluene / 24 h / -20 °C

2: 53 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, molecular sieves (4 Angstroem) / CH₂Cl₂ / 4 h / 22 °C

3: 81 percent / iBu₂AlH / CH₂Cl₂ / 2 h / -78 °C

4: 98 percent / (COCl)2, DMSO, Et₃N / CH₂Cl₂ / 2 h / -78 °C

5: 1.) Mg / 2.) THF, 22 deg C, 6 h

6: 92 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.33 h / 22 °C

7: 1.) Cp₂TiCl₂ / 2.) THF, 22 deg C, 1 h

With bis(cyclopentadienyl)titanium dichloride; n-butyllithium; oxalyl dichloride; 4 A molecular sieve; diisobutylaluminium hydride; Dess-Martin periodane; magnesium; dimethyl sulfoxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; toluene;