[(R)-2-((R)-Benzo[1,3]dioxol-5-yl-hydroxy-methyl)-piperidin-1-yl]-(3,4,5-trimethoxy-phenyl)-methanone

Base Information

• Chemical Name: [(R)-2-((R)-Benzo[1,3]dioxol-5-yl-hydroxy-methyl)-piperidin-1-yl]-(3,4,5-trimethoxy-phenyl)-methanone
• CAS No.: 152088-25-0
• Molecular Formula: C₂₃H₂₇NO₇
• Molecular Weight: 429.47
• Mol file: 152088-25-0.mol

Synonyms:[(R)-2-((R)-Benzo[1,3]dioxol-5-yl-hydroxy-methyl)-piperidin-1-yl]-(3,4,5-trimethoxy-phenyl)-methanone

Chemical Property of [(R)-2-((R)-Benzo[1,3]dioxol-5-yl-hydroxy-methyl)-piperidin-1-yl]-(3,4,5-trimethoxy-phenyl)-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(R)-2-((R)-Benzo[1,3]dioxol-5-yl-hydroxy-methyl)-piperidin-1-yl]-(3,4,5-trimethoxy-phenyl)-methanone

There total 6 articles about [(R)-2-((R)-Benzo[1,3]dioxol-5-yl-hydroxy-methyl)-piperidin-1-yl]-(3,4,5-trimethoxy-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3,4,5-Trimethoxybenzoyl chloride (4521-61-3) + (R)-Benzo[1,3]dioxol-5-yl-(R)-piperidin-2-yl-methanol (152088-24-9) → [(R)-2-((R)-Benzo[1,3]dioxol-5-yl-hydroxy-methyl)-piperidin-1-yl]-(3,4,5-trimethoxy-phenyl)-methanone (152088-25-0)

Guidance literature:

With sodium hydroxide; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1016/S0040-4020(01)89913-0

Reference yield: 73.0%

(R)-Benzo[1,3]dioxol-5-yl-(R)-piperidin-2-yl-methanol (152088-24-9) + 5-(chloromethyl)-1,2,3-trimethoxybenzene (3840-30-0) → [(R)-2-((R)-Benzo[1,3]dioxol-5-yl-hydroxy-methyl)-piperidin-1-yl]-(3,4,5-trimethoxy-phenyl)-methanone (152088-25-0)

Guidance literature:

With sodium hydroxide; In dichloromethane; Ambient temperature;

DOI:10.1016/0040-4039(95)01173-F

Reference yield:

(3R,5S,8aR)-5-((R)-Benzo[1,3]dioxol-5-yl-hydroxy-methyl)-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-5-carbonitrile (1025961-96-9) → [(R)-2-((R)-Benzo[1,3]dioxol-5-yl-hydroxy-methyl)-piperidin-1-yl]-(3,4,5-trimethoxy-phenyl)-methanone (152088-25-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / NaBH₄ / ethanol / 12 h / Heating

2: 99 percent / H₂ / 10percent Pd/C / ethanol / 12 h / 760 Torr

3: 73 percent / 10percent aq. NaOH / CH₂Cl₂ / 2 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1016/S0040-4020(01)89913-0

upstream raw materials:

3,4,5-Trimethoxybenzoyl chloride

(R)-Benzo[1,3]dioxol-5-yl-(R)-piperidin-2-yl-methanol

5-(chloromethyl)-1,2,3-trimethoxybenzene

piperonal

Downstream raw materials:

[(R)-2-((R)-Benzo[1,3]dioxol-5-yl-benzyloxy-methyl)-piperidin-1-yl]-(3,4,5-trimethoxy-phenyl)-methanone