[(3aS,4R,5S,9bR)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2,5-trimethyl-3a,4,5,6,7,8,9,9b-octahydro-naphtho[1,2-d][1,3]dioxol-4-yl]-acetaldehyde

Base Information

Chemical Name:[(3aS,4R,5S,9bR)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2,5-trimethyl-3a,4,5,6,7,8,9,9b-octahydro-naphtho[1,2-d][1,3]dioxol-4-yl]-acetaldehyde
CAS No.:143121-48-6
Molecular Formula:C₃₃H₄₄O₄Si
Molecular Weight:532.795
Hs Code.:

Synonyms:[(3aS,4R,5S,9bR)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2,5-trimethyl-3a,4,5,6,7,8,9,9b-octahydro-naphtho[1,2-d][1,3]dioxol-4-yl]-acetaldehyde

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Chemical Property of [(3aS,4R,5S,9bR)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2,5-trimethyl-3a,4,5,6,7,8,9,9b-octahydro-naphtho[1,2-d][1,3]dioxol-4-yl]-acetaldehyde

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Technology Process of [(3aS,4R,5S,9bR)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2,5-trimethyl-3a,4,5,6,7,8,9,9b-octahydro-naphtho[1,2-d][1,3]dioxol-4-yl]-acetaldehyde

There total 4 articles about [(3aS,4R,5S,9bR)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2,5-trimethyl-3a,4,5,6,7,8,9,9b-octahydro-naphtho[1,2-d][1,3]dioxol-4-yl]-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 143121-47-5
[(3aS,4R,5S,9bR)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2,5-trimethyl-3a,4,5,6,7,8,9,9b-octahydro-naphtho[1,2-d][1,3]dioxol-4-yl]-acetonitrile

: 143121-48-6
[(3aS,4R,5S,9bR)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2,5-trimethyl-3a,4,5,6,7,8,9,9b-octahydro-naphtho[1,2-d][1,3]dioxol-4-yl]-acetaldehyde

Guidance literature:: With diisobutylaluminium hydride; In hexane; toluene; at -78 ℃; for 3h;
DOI:10.1021/jo00044a025

Reference yield:

: 143121-45-3
[(3aR,4R,5R,9bS)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2,5-trimethyl-3a,4,5,6,7,8,9,9b-octahydro-naphtho[1,2-d][1,3]dioxol-4-yl]-methanol

: 143121-48-6
[(3aS,4R,5S,9bR)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2,5-trimethyl-3a,4,5,6,7,8,9,9b-octahydro-naphtho[1,2-d][1,3]dioxol-4-yl]-acetaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / NEt₃ / CH₂Cl₂ / 1 h / 25 °C

2: 94 percent / dimethylsulfoxide / 15 h / 65 °C

3: 94 percent / diisobutylaluminium hydride / toluene; hexane / 3 h / -78 °C

With diisobutylaluminium hydride; triethylamine; In hexane; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/jo00044a025

Reference yield:

: 143121-44-2
2,2-Dimethyl-propionic acid (3aS,4S,5S,9bR)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2,5-trimethyl-3a,4,5,6,7,8,9,9b-octahydro-naphtho[1,2-d][1,3]dioxol-4-ylmethyl ester

: 143121-48-6
[(3aS,4R,5S,9bR)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2,5-trimethyl-3a,4,5,6,7,8,9,9b-octahydro-naphtho[1,2-d][1,3]dioxol-4-yl]-acetaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / methyllithium / CH₂Cl₂; diethyl ether / 1.5 h / -78 °C

2: 99 percent / NEt₃ / CH₂Cl₂ / 1 h / 25 °C

3: 94 percent / dimethylsulfoxide / 15 h / 65 °C

4: 94 percent / diisobutylaluminium hydride / toluene; hexane / 3 h / -78 °C

With methyllithium; diisobutylaluminium hydride; triethylamine; In diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/jo00044a025