1-(tetrahydropyran-2-yloxy)-20-(tert-butyldiphenylsilyloxy)-eicosa-6-yne

Base Information

Chemical Name:1-(tetrahydropyran-2-yloxy)-20-(tert-butyldiphenylsilyloxy)-eicosa-6-yne
CAS No.:622842-21-1
Molecular Formula:C₄₁H₆₄O₃Si
Molecular Weight:633.043
Hs Code.:

Synonyms:1-(tetrahydropyran-2-yloxy)-20-(tert-butyldiphenylsilyloxy)-eicosa-6-yne

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Chemical Property of 1-(tetrahydropyran-2-yloxy)-20-(tert-butyldiphenylsilyloxy)-eicosa-6-yne

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Technology Process of 1-(tetrahydropyran-2-yloxy)-20-(tert-butyldiphenylsilyloxy)-eicosa-6-yne

There total 7 articles about 1-(tetrahydropyran-2-yloxy)-20-(tert-butyldiphenylsilyloxy)-eicosa-6-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: lithium 1-(tetrahydropyran-2-yloxy)-hept-6-ynide

: 622842-42-6
1-(tert-butyldiphenylsilyloxy)-13-(bromo)-tridecane

: 622842-21-1
1-(tetrahydropyran-2-yloxy)-20-(tert-butyldiphenylsilyloxy)-eicosa-6-yne

Guidance literature:: In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; at -40 - 20 ℃;

Reference yield:

: 928-90-5
5-hexyl-1-ol

: 622842-21-1
1-(tetrahydropyran-2-yloxy)-20-(tert-butyldiphenylsilyloxy)-eicosa-6-yne

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / AgNO₃; pyridine / tetrahydrofuran / 12 h / 20 °C

2: n-BuLi; HMPA / tetrahydrofuran; hexane / 14 h / -40 - 20 °C

3: 92 percent / pyridinium p-toluenesulfonate; MeOH / 20 °C

4: 91 percent / PPh₃; CBr₄ / CH₂Cl₂ / 0 °C

5: 99 percent / H₂ / Pd/C / methanol / 2.5 h / 760 Torr

6: 67 percent / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / -40 - 20 °C

With pyridine; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; carbon tetrabromide; hydrogen; pyridinium p-toluenesulfonate; silver nitrate; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane;

Reference yield:

: 128217-23-2
1-(tert-butyldiphenylsilyloxy)-5-hexyne

: 622842-21-1
1-(tetrahydropyran-2-yloxy)-20-(tert-butyldiphenylsilyloxy)-eicosa-6-yne

Guidance literature:: Multi-step reaction with 5 steps

1: n-BuLi; HMPA / tetrahydrofuran; hexane / 14 h / -40 - 20 °C

2: 92 percent / pyridinium p-toluenesulfonate; MeOH / 20 °C

3: 91 percent / PPh₃; CBr₄ / CH₂Cl₂ / 0 °C

4: 99 percent / H₂ / Pd/C / methanol / 2.5 h / 760 Torr

5: 67 percent / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / -40 - 20 °C

With methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; carbon tetrabromide; hydrogen; pyridinium p-toluenesulfonate; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane;