3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-thiophene-2-carboxylic acid benzylamide

Base Information

Chemical Name:3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-thiophene-2-carboxylic acid benzylamide
CAS No.:1265225-49-7
Molecular Formula:C₁₈H₁₅N₅OS
Molecular Weight:349.416
Hs Code.:

Synonyms:3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-thiophene-2-carboxylic acid benzylamide

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Chemical Property of 3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-thiophene-2-carboxylic acid benzylamide

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Technology Process of 3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-thiophene-2-carboxylic acid benzylamide

There total 3 articles about 3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-thiophene-2-carboxylic acid benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-thiophene-2-carboxylic acid methyl ester hydrochloride

: 100-46-9
benzylamine

: 1265225-49-7
3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-thiophene-2-carboxylic acid benzylamide

Guidance literature:: benzylamine; With trimethylaluminum; In toluene; at 25 ℃; for 1h; Inert atmosphere; Sealed tube;

3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-thiophene-2-carboxylic acid methyl ester hydrochloride; In toluene; at 105 ℃;

Reference yield:

: 22288-78-4
Methyl 3-aminothiophene-2-carboxylate

: 1265225-49-7
3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-thiophene-2-carboxylic acid benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / tert-butyl alcohol / 3 h / 75 °C / Microwave irradiation

2.1: trimethylaluminum / toluene / 1 h / 25 °C / Inert atmosphere; Sealed tube

2.2: 105 °C

With hydrogenchloride; trimethylaluminum; In toluene; tert-butyl alcohol;

Reference yield:

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 1265225-49-7
3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-thiophene-2-carboxylic acid benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / tert-butyl alcohol / 3 h / 75 °C / Microwave irradiation

2.1: trimethylaluminum / toluene / 1 h / 25 °C / Inert atmosphere; Sealed tube

2.2: 105 °C

With hydrogenchloride; trimethylaluminum; In toluene; tert-butyl alcohol;