dibenzyl 5-((diethoxyphosphoryl)difluoromethyl)-1H-indole-1,2-dicarboxylate

Base Information

Chemical Name:dibenzyl 5-((diethoxyphosphoryl)difluoromethyl)-1H-indole-1,2-dicarboxylate
CAS No.:1233086-49-1
Molecular Formula:C₂₉H₂₈F₂NO₇P
Molecular Weight:571.514
Hs Code.:

Synonyms:dibenzyl 5-((diethoxyphosphoryl)difluoromethyl)-1H-indole-1,2-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dibenzyl 5-((diethoxyphosphoryl)difluoromethyl)-1H-indole-1,2-dicarboxylate

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Technology Process of dibenzyl 5-((diethoxyphosphoryl)difluoromethyl)-1H-indole-1,2-dicarboxylate

There total 3 articles about dibenzyl 5-((diethoxyphosphoryl)difluoromethyl)-1H-indole-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1233086-48-0
dibenzyl 5-((diethoxyphosphoryl)methyl)-1H-indole-1,2-dicarboxylate

: 1233086-49-1
dibenzyl 5-((diethoxyphosphoryl)difluoromethyl)-1H-indole-1,2-dicarboxylate

Guidance literature:: With sodium hexamethyldisilazane; N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1021/acs.jmedchem.9b01530

Reference yield:

: 1-tert-butyl 2-ethyl 5-((diethoxyphosphoryl)methyl)-1H-indole-1,2-dicarboxylate

: 1233086-49-1
dibenzyl 5-((diethoxyphosphoryl)difluoromethyl)-1H-indole-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium(IV) isopropylate / 12 h / 100 °C / Inert atmosphere

2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

2.2: 12 h / 0 - 20 °C / Inert atmosphere

3.1: N-fluorobis(benzenesulfon)imide; sodium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

With titanium(IV) isopropylate; sodium hexamethyldisilazane; sodium hydride; N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; mineral oil;
DOI:10.1021/acs.jmedchem.9b01530

Reference yield:

: 1233086-47-9
benzyl 5-((diethoxyphosphoryl)methyl)-1H-indole-2-carboxylate

: 501-53-1,94274-21-2
benzyl chloroformate

: 1233086-49-1
dibenzyl 5-((diethoxyphosphoryl)difluoromethyl)-1H-indole-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

1.2: 12 h / 0 - 20 °C / Inert atmosphere

2.1: N-fluorobis(benzenesulfon)imide; sodium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

With sodium hexamethyldisilazane; sodium hydride; N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; mineral oil;
DOI:10.1021/acs.jmedchem.9b01530