Technology Process of 1'-benzyl-3,3'-bis-(2-hydroxyethyl)-1-methyl-1,1',3,3'-tetrahydro-[3S,3'S]biindolyl-2,2'-dione
There total 9 articles about 1'-benzyl-3,3'-bis-(2-hydroxyethyl)-1-methyl-1,1',3,3'-tetrahydro-[3S,3'S]biindolyl-2,2'-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C28H26N2O4;
With
sodium periodate;
In
tetrahydrofuran; water;
at 20 ℃;
for 12h;
With
sodium tetrahydroborate;
In
methanol;
at 20 ℃;
for 0.166667h;
DOI:10.1016/S0040-4020(03)00855-X
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 76 percent / AcOH; HCl / 6 h / 110 °C
2.1: 97 percent / Cs2CO3 / dimethylformamide / 24 h / 20 °C
3.1: 88 percent / H2 / PtO2 / ethyl acetate / 20 °C / 760 Torr
4.1: LHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.5 h / -40 °C
4.2: 75 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 13 h / -35 - 20 °C
5.1: 98 percent / camphorsulfonic acid / methanol; CH2Cl2 / 3 h / 20 °C
6.1: NaIO4 / H2O; tetrahydrofuran / 12 h / 20 °C
6.2: 87 percent / NaBH4 / methanol / 0.17 h / 20 °C
With
hydrogenchloride; sodium periodate; camphor-10-sulfonic acid; hydrogen; caesium carbonate; acetic acid; lithium hexamethyldisilazane;
platinum(IV) oxide;
In
tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(03)00855-X
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 99 percent / NaH / dimethylformamide / 0.25 h
2.1: 76 percent / AcOH; HCl / 6 h / 110 °C
3.1: 97 percent / Cs2CO3 / dimethylformamide / 24 h / 20 °C
4.1: 88 percent / H2 / PtO2 / ethyl acetate / 20 °C / 760 Torr
5.1: LHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.5 h / -40 °C
5.2: 75 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 13 h / -35 - 20 °C
6.1: 98 percent / camphorsulfonic acid / methanol; CH2Cl2 / 3 h / 20 °C
7.1: NaIO4 / H2O; tetrahydrofuran / 12 h / 20 °C
7.2: 87 percent / NaBH4 / methanol / 0.17 h / 20 °C
With
hydrogenchloride; sodium periodate; camphor-10-sulfonic acid; hydrogen; sodium hydride; caesium carbonate; acetic acid; lithium hexamethyldisilazane;
platinum(IV) oxide;
In
tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(03)00855-X
