ethyl 10-(tert-butyldiphenylsilyloxy)-2-fluoro-2-(pyrimidin-2-ylsulfonyl)decanoate

Base Information

Chemical Name:ethyl 10-(tert-butyldiphenylsilyloxy)-2-fluoro-2-(pyrimidin-2-ylsulfonyl)decanoate
CAS No.:288400-71-5
Molecular Formula:C₃₂H₄₃FN₂O₅SSi
Molecular Weight:614.854
Hs Code.:

Synonyms:ethyl 10-(tert-butyldiphenylsilyloxy)-2-fluoro-2-(pyrimidin-2-ylsulfonyl)decanoate

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Chemical Property of ethyl 10-(tert-butyldiphenylsilyloxy)-2-fluoro-2-(pyrimidin-2-ylsulfonyl)decanoate

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Technology Process of ethyl 10-(tert-butyldiphenylsilyloxy)-2-fluoro-2-(pyrimidin-2-ylsulfonyl)decanoate

There total 5 articles about ethyl 10-(tert-butyldiphenylsilyloxy)-2-fluoro-2-(pyrimidin-2-ylsulfonyl)decanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50816-19-8
8-bromooctanol

: 288400-71-5
ethyl 10-(tert-butyldiphenylsilyloxy)-2-fluoro-2-(pyrimidin-2-ylsulfonyl)decanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / pyridine / 18 h / 20 °C

2: 75 percent / NaH / dimethylformamide / 18 h / 20 - 50 °C

3: 72 percent / KH; Selectfluor / tetrahydrofuran; dimethylformamide / 20 °C

With potassium hydride; sodium hydride; Selectfluor; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide; 1: Substitution / 2: Alkylation / 3: Fluorination;
DOI:10.1021/jo000342n

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 288400-71-5
ethyl 10-(tert-butyldiphenylsilyloxy)-2-fluoro-2-(pyrimidin-2-ylsulfonyl)decanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / pyridine / 18 h / 20 °C

2: 75 percent / NaH / dimethylformamide / 18 h / 20 - 50 °C

3: 72 percent / KH; Selectfluor / tetrahydrofuran; dimethylformamide / 20 °C

With potassium hydride; sodium hydride; Selectfluor; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide; 1: Substitution / 2: Alkylation / 3: Fluorination;
DOI:10.1021/jo000342n

Reference yield:

: 172995-43-6
8-bromo-1-(tert-butyldiphenylsilyloxy)-octane

: 288400-71-5
ethyl 10-(tert-butyldiphenylsilyloxy)-2-fluoro-2-(pyrimidin-2-ylsulfonyl)decanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / NaH / dimethylformamide / 18 h / 20 - 50 °C

2: 72 percent / KH; Selectfluor / tetrahydrofuran; dimethylformamide / 20 °C

With potassium hydride; sodium hydride; Selectfluor; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Alkylation / 2: Fluorination;
DOI:10.1021/jo000342n