(R)-2-((R)-1,2-Bis-benzyloxy-ethyl)-6-(tert-butyl-dimethyl-silanyloxy)-hexanal

Base Information

Chemical Name:(R)-2-((R)-1,2-Bis-benzyloxy-ethyl)-6-(tert-butyl-dimethyl-silanyloxy)-hexanal
CAS No.:159266-68-9
Molecular Formula:C₂₈H₄₂O₄Si
Molecular Weight:470.725
Hs Code.:

Synonyms:(R)-2-((R)-1,2-Bis-benzyloxy-ethyl)-6-(tert-butyl-dimethyl-silanyloxy)-hexanal

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Chemical Property of (R)-2-((R)-1,2-Bis-benzyloxy-ethyl)-6-(tert-butyl-dimethyl-silanyloxy)-hexanal

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Technology Process of (R)-2-((R)-1,2-Bis-benzyloxy-ethyl)-6-(tert-butyl-dimethyl-silanyloxy)-hexanal

There total 5 articles about (R)-2-((R)-1,2-Bis-benzyloxy-ethyl)-6-(tert-butyl-dimethyl-silanyloxy)-hexanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 159266-80-5
(R)-2-((R)-1,2-Bis-benzyloxy-ethyl)-6-(tert-butyl-dimethyl-silanyloxy)-hexanoic acid methoxy-methyl-amide

: 159266-68-9
(R)-2-((R)-1,2-Bis-benzyloxy-ethyl)-6-(tert-butyl-dimethyl-silanyloxy)-hexanal

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1016/S0040-4039(00)73455-1

Reference yield:

: 60656-87-3
benzyloxyacetoaldehyde

: 159266-68-9
(R)-2-((R)-1,2-Bis-benzyloxy-ethyl)-6-(tert-butyl-dimethyl-silanyloxy)-hexanal

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Bu₂BOTf, Et₃N / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, -78 deg C to 0 deg C

2: 92 percent / Me₃Al / 0 deg C to room temperature

3: 98 percent / NaH, Bu₄NI / dimethylformamide / 0 deg C to room temperature

4: 93 percent / DIBAL / tetrahydrofuran / 2 h / -78 °C

With di-n-butylboryl trifluoromethanesulfonate; trimethylaluminum; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)73455-1

Reference yield:

: (4R,5S)-3-[6-(tert-Butyl-dimethyl-silanyloxy)-hexanoyl]-4-methyl-5-phenyl-oxazolidin-2-one

: 159266-68-9
(R)-2-((R)-1,2-Bis-benzyloxy-ethyl)-6-(tert-butyl-dimethyl-silanyloxy)-hexanal

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Bu₂BOTf, Et₃N / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, -78 deg C to 0 deg C

2: 92 percent / Me₃Al / 0 deg C to room temperature

3: 98 percent / NaH, Bu₄NI / dimethylformamide / 0 deg C to room temperature

4: 93 percent / DIBAL / tetrahydrofuran / 2 h / -78 °C

With di-n-butylboryl trifluoromethanesulfonate; trimethylaluminum; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)73455-1