Technology Process of (4R,5R,6S)-5,6-dibenzyloxyoct-7-en-4-yl (2R)-2-benzyloxyhex-5-enoate
There total 10 articles about (4R,5R,6S)-5,6-dibenzyloxyoct-7-en-4-yl (2R)-2-benzyloxyhex-5-enoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: tetrahydrofuran / -78 - 20 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 60 °C / Inert atmosphere
3.2: 3 h / 20 - 60 °C / Inert atmosphere
4.1: water; trifluoroacetic acid / dichloromethane / 2.5 h / 0 °C
5.1: pyridine; dmap / 2 h / 0 °C
6.1: potassium carbonate / methanol / 3 h / 20 °C
7.1: magnesium / tetrahydrofuran
7.2: 0.25 h / -50 °C
8.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3 h / 0 - 20 °C
With
pyridine; dmap; tetrabutyl ammonium fluoride; water; sodium hydride; potassium carbonate; magnesium; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane; mineral oil;
1.1: Grignard reaction;
DOI:10.1016/j.tetasy.2012.05.011
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: pyridine; dmap / 2 h / 0 °C
2.1: potassium carbonate / methanol / 3 h / 20 °C
3.1: magnesium / tetrahydrofuran
3.2: 0.25 h / -50 °C
4.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3 h / 0 - 20 °C
With
pyridine; dmap; potassium carbonate; magnesium; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.tetasy.2012.05.011
