(S)-tert-butyl 3-chloro-3-(4-fluorophenyl)-5-methyl-2-oxoindoline-1-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 3-chloro-3-(4-fluorophenyl)-5-methyl-2-oxoindoline-1-carboxylate
CAS No.:1273020-62-4
Molecular Formula:C₂₀H₁₉ClFNO₃
Molecular Weight:375.827
Hs Code.:

Synonyms:(S)-tert-butyl 3-chloro-3-(4-fluorophenyl)-5-methyl-2-oxoindoline-1-carboxylate

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Chemical Property of (S)-tert-butyl 3-chloro-3-(4-fluorophenyl)-5-methyl-2-oxoindoline-1-carboxylate

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Technology Process of (S)-tert-butyl 3-chloro-3-(4-fluorophenyl)-5-methyl-2-oxoindoline-1-carboxylate

There total 3 articles about (S)-tert-butyl 3-chloro-3-(4-fluorophenyl)-5-methyl-2-oxoindoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 923568-88-1
tert-butyl 3-(4-fluorophenyl)-5-methyl-2-oxoindoline-1-carboxylate

: 1273020-62-4
(S)-tert-butyl 3-chloro-3-(4-fluorophenyl)-5-methyl-2-oxoindoline-1-carboxylate

Guidance literature:: With N-chloro-succinimide; Ca[(S)-VAPOL-Phosphate]2; In Isopropyl acetate; at 20 ℃; for 0.5h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja109824x

Reference yield: 95.0%

: 1273020-62-4
(S)-tert-butyl 3-chloro-3-(4-fluorophenyl)-5-methyl-2-oxoindoline-1-carboxylate

Guidance literature:: With N-chloro-succinimide; C₉₄H₁₂₃N₄O₄P; In diethyl ether; at 20 ℃; for 0.25h; enantioselective reaction;

Reference yield:

: 923568-88-1
tert-butyl 3-(4-fluorophenyl)-5-methyl-2-oxoindoline-1-carboxylate

: 1273020-62-4
(S)-tert-butyl 3-chloro-3-(4-fluorophenyl)-5-methyl-2-oxoindoline-1-carboxylate

: 1335112-39-4
(R)-tert-butyl 3-chloro-3-(4-fluorophenyl)-5-methyl-2-oxoindoline-1-carboxylate

Guidance literature:: With N-chloro-succinimide; nickel(II) tetrafluoroborate hexahydrate; (R)-N,N′-bis(2-quinolylmethylene)-1,1′-binaphthyl-2,2′-diamine; In acetonitrile; at 0 ℃; for 1h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1016/j.tetasy.2011.06.021