1-benzyl-3-chloro-5-(potassium trifluoroboryl)-4-(trimethylsilyl)pyridine-2-(1H)-one

Base Information

Chemical Name:1-benzyl-3-chloro-5-(potassium trifluoroboryl)-4-(trimethylsilyl)pyridine-2-(1H)-one
CAS No.:1417647-19-8
Molecular Formula:C₁₅H₁₇BClF₃NOSi*K
Molecular Weight:397.749
Hs Code.:

Synonyms:1-benzyl-3-chloro-5-(potassium trifluoroboryl)-4-(trimethylsilyl)pyridine-2-(1H)-one

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Chemical Property of 1-benzyl-3-chloro-5-(potassium trifluoroboryl)-4-(trimethylsilyl)pyridine-2-(1H)-one

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Technology Process of 1-benzyl-3-chloro-5-(potassium trifluoroboryl)-4-(trimethylsilyl)pyridine-2-(1H)-one

There total 4 articles about 1-benzyl-3-chloro-5-(potassium trifluoroboryl)-4-(trimethylsilyl)pyridine-2-(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1010101-15-1
1-benzyl-3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trimethylsilyl)pyridin-2(1H)-one

: 1417647-19-8
1-benzyl-3-chloro-5-(potassium trifluoroboryl)-4-(trimethylsilyl)pyridine-2-(1H)-one

Guidance literature:: With potassium hydrogen difluoride; In tetrahydrofuran; water; at 0 ℃;
DOI:10.1016/j.tet.2012.12.010

Reference yield:

: 1066-54-2
trimethylsilylacetylene

: 1417647-19-8
1-benzyl-3-chloro-5-(potassium trifluoroboryl)-4-(trimethylsilyl)pyridine-2-(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether; hexane / 1.5 h / -30 - 0 °C / Inert atmosphere

1.2: -50 °C / Inert atmosphere

1.3: 1.5 h / -50 - -10 °C / Inert atmosphere

2.1: 180 °C

3.1: potassium hydrogen difluoride / water; tetrahydrofuran / 0 °C

With n-butyllithium; potassium hydrogen difluoride; In tetrahydrofuran; diethyl ether; hexane; water;
DOI:10.1016/j.tet.2012.12.010

Reference yield:

: 159087-46-4
4,4,5,5-tetramethyl-2-trimethylsilanylethynyl-[1,3,2]dioxaborolane

: 1417647-19-8
1-benzyl-3-chloro-5-(potassium trifluoroboryl)-4-(trimethylsilyl)pyridine-2-(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 180 °C

2: potassium hydrogen difluoride / water; tetrahydrofuran / 0 °C

With potassium hydrogen difluoride; In tetrahydrofuran; water;
DOI:10.1016/j.tet.2012.12.010