2-(CHLOROMETHYL)-6-FLUORO-1H-BENZO[D]IMIDAZOLE

Base Information

• Chemical Name: 2-(CHLOROMETHYL)-6-FLUORO-1H-BENZO[D]IMIDAZOLE
• CAS No.: 156144-42-2
• Molecular Formula: C8H6 Cl F N2
• Molecular Weight: 184.6
• Hs Code.: 2933998090
• Mol file: 156144-42-2.mol

Synonyms:1H-Benzimidazole,2-(chloromethyl)-5-fluoro- (9CI); 2-Chloromethyl-5-fluoro-1H-benzimidazole;5-Fluoro-2-chloromethylbenzimidazole

Chemical Property of 2-(CHLOROMETHYL)-6-FLUORO-1H-BENZO[D]IMIDAZOLE

Chemical Property:

• PSA: 28.68000
• LogP: 2.44080

Purity/Quality:

98%min ^*data from raw suppliers

2-(chloromethyl)-5-fluoro-1H-benzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(CHLOROMETHYL)-6-FLUORO-1H-BENZO[D]IMIDAZOLE

There total 5 articles about 2-(CHLOROMETHYL)-6-FLUORO-1H-BENZO[D]IMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-fluoro-1,2-phenylenediamine (367-31-7) + chloroacetic acid (79-11-8) → 6-fluoro-(2-chloromethyl)benzimidazole (156144-42-2)

Guidance literature:

4-fluoro-1,2-phenylenediamine; chloroacetic acid; With hydrogenchloride; In water; for 2h; Heating / reflux;

With sodium carbonate; In water; at 25 ℃;

Reference yield: 86.0%

4-fluoro-1,2-phenylenediamine (367-31-7) + chloroacetic acid (79-11-8) → 2-(chloromethyl)-5-fluoro-1H-1,3-benzodiazole (156144-42-2)

Guidance literature:

4-fluoro-1,2-phenylenediamine; chloroacetic acid; With water; In water; at 95 ℃; for 6h;

With sodium hydrogencarbonate; In water; pH=9;

Reference yield: 80.0%

(5-fluoro-1H-benzimidazole-2-yl)methanol (39811-07-9) → 2-(chloromethyl)-5-fluoro-1H-1,3-benzodiazole (156144-42-2)

Guidance literature:

With thionyl chloride; In dichloromethane; at 10 ℃; for 5h;

DOI:10.3390/molecules200815206

upstream raw materials:

4-fluoro-1,2-phenylenediamine

chloroacetic acid

(5-fluoro-1H-benzimidazole-2-yl)methanol

Refernces

• 1、 -. "TRANSGLUTAMINASE 2 (TG2) INHIBITORS". Paragraph 00585. . Retrieved 2020/03/02.
• 2、 -. "NOVEL BENZIMIDAZOLE BASED EGFR INHIBITORS". Page/Page column 13 ; 14. . Retrieved 2016/06/15.