diethyl 5,5-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(4'-chloro-4-oxo-1,2,3,4-tetrahydro-[1,1'-biphenyl]-3-carboxylate)

Base Information

Chemical Name:diethyl 5,5-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(4'-chloro-4-oxo-1,2,3,4-tetrahydro-[1,1'-biphenyl]-3-carboxylate)
CAS No.:1447968-16-2
Molecular Formula:C₃₈H₃₉Cl₂NO₆
Molecular Weight:676.637
Hs Code.:

Synonyms:diethyl 5,5-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(4'-chloro-4-oxo-1,2,3,4-tetrahydro-[1,1'-biphenyl]-3-carboxylate)

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Chemical Property of diethyl 5,5-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(4'-chloro-4-oxo-1,2,3,4-tetrahydro-[1,1'-biphenyl]-3-carboxylate)

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Technology Process of diethyl 5,5-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(4'-chloro-4-oxo-1,2,3,4-tetrahydro-[1,1'-biphenyl]-3-carboxylate)

There total 3 articles about diethyl 5,5-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(4'-chloro-4-oxo-1,2,3,4-tetrahydro-[1,1'-biphenyl]-3-carboxylate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1447967-99-8
(2E,2'E)-1,1'-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(3-(4-chlorophenyl)prop-2-en-1-one)

: 141-97-9
ethyl acetoacetate

: 1447968-16-2
diethyl 5,5-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(4'-chloro-4-oxo-1,2,3,4-tetrahydro-[1,1'-biphenyl]-3-carboxylate)

Guidance literature:: With piperidine; In butan-1-ol; for 8h; Reflux;
DOI:10.1016/j.saa.2012.12.069

Reference yield:

: 1081-09-0
3,5-diacetyl-1,4-dihydro-2,4,6-trimethylpyridine

: 1447968-16-2
diethyl 5,5-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(4'-chloro-4-oxo-1,2,3,4-tetrahydro-[1,1'-biphenyl]-3-carboxylate)

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / 20 °C

2: piperidine / butan-1-ol / 8 h / Reflux

With piperidine; potassium hydroxide; In butan-1-ol; 2: |Michael Addition;
DOI:10.1016/j.saa.2012.12.069

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1447968-16-2
diethyl 5,5-(2,4,6-trimethyl-1,4-dihydropyridine-3,5-diyl)bis(4'-chloro-4-oxo-1,2,3,4-tetrahydro-[1,1'-biphenyl]-3-carboxylate)

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / 20 °C

2: piperidine / butan-1-ol / 8 h / Reflux

With piperidine; potassium hydroxide; In butan-1-ol; 2: |Michael Addition;
DOI:10.1016/j.saa.2012.12.069