4-[3-Oxo-3-piperidin-1-yl-2-(toluene-4-sulfonylamino)-propyl]-benzamidine; hydriodide

Base Information

• Chemical Name: 4-[3-Oxo-3-piperidin-1-yl-2-(toluene-4-sulfonylamino)-propyl]-benzamidine; hydriodide
• CAS No.: 71131-95-8
• Molecular Formula: C₂₂H₂₈N₄O₃S*HI
• Molecular Weight: 556.468
• Mol file: 71131-95-8.mol

Synonyms:4-[3-Oxo-3-piperidin-1-yl-2-(toluene-4-sulfonylamino)-propyl]-benzamidine; hydriodide

Chemical Property of 4-[3-Oxo-3-piperidin-1-yl-2-(toluene-4-sulfonylamino)-propyl]-benzamidine; hydriodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[3-Oxo-3-piperidin-1-yl-2-(toluene-4-sulfonylamino)-propyl]-benzamidine; hydriodide

There total 13 articles about 4-[3-Oxo-3-piperidin-1-yl-2-(toluene-4-sulfonylamino)-propyl]-benzamidine; hydriodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-[3-Oxo-3-piperidin-1-yl-2-(toluene-4-sulfonylamino)-propyl]-thiobenzimidic acid methyl ester; hydriodide (71079-02-2) → 4-[3-Oxo-3-piperidin-1-yl-2-(toluene-4-sulfonylamino)-propyl]-benzamidine; hydriodide (71131-95-8)

Guidance literature:

With ammonium acetate; In ethanol; at 70 - 80 ℃; for 2.5h;

Reference yield:

piperidine (110-89-4) → 4-[3-Oxo-3-piperidin-1-yl-2-(toluene-4-sulfonylamino)-propyl]-benzamidine; hydriodide (71131-95-8)

Guidance literature:

Multi-step reaction with 5 steps

1: benzene / 1.5 h / Ambient temperature

2: copper sulfate / pyridine; dimethylformamide

3: 90 percent / H₂S(gas), TEA / pyridine / 72 h / Ambient temperature

4: 83 percent / acetone / 27 h / Ambient temperature

5: 70 percent / Ammonium acetate / ethanol / 2.5 h / 70 - 80 °C

With ammonium acetate; copper(I) sulfate; TEA; hydrogen sulfide; copper(II) sulfate; In pyridine; ethanol; N,N-dimethyl-formamide; acetone; benzene;

Reference yield:

N-acetyl-4-cyano-α-(ethoxycarbonyl)phenylalanine ethyl ester (52117-01-8) → 4-[3-Oxo-3-piperidin-1-yl-2-(toluene-4-sulfonylamino)-propyl]-benzamidine; hydriodide (71131-95-8)

Guidance literature:

Multi-step reaction with 6 steps

2: SOCl₂ / 1 h / Heating

3: 63 percent / benzene / 1.5 h / Ambient temperature

4: 90 percent / H₂S(gas), TEA / pyridine / 72 h / Ambient temperature

5: 83 percent / acetone / 27 h / Ambient temperature

6: 70 percent / Ammonium acetate / ethanol / 2.5 h / 70 - 80 °C

With ammonium acetate; thionyl chloride; TEA; hydrogen sulfide; In pyridine; ethanol; acetone; benzene;

upstream raw materials:

4-[3-Oxo-3-piperidin-1-yl-2-(toluene-4-sulfonylamino)-propyl]-thiobenzimidic acid methyl ester; hydriodide

piperidine

N-[1-(4-Bromo-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-4-methyl-benzenesulfonamide

4-[3-oxo-3-piperidin-1-yl-2-(toluene-4-sulfonylamino)-propyl]-thiobenzamide

Downstream raw materials:

4-[3-Oxo-3-piperidin-1-yl-2-(toluene-4-sulfonylamino)-propyl]-benzamidine; hydrochloride