2-Methoxy-2-naphthalen-2-yl-propionic acid

Base Information

Chemical Name:2-Methoxy-2-naphthalen-2-yl-propionic acid
CAS No.:299397-14-1
Molecular Formula:C₁₄H₁₄O₃
Molecular Weight:230.263
Hs Code.:
DSSTox Substance ID:DTXSID80583306
Nikkaji Number:J1.587.555K

Synonyms:2-Methoxy-2-naphthalen-2-yl-propionic acid;63049-37-6;2-Methoxy-2-(naphthalen-2-yl)propanoic acid;SCHEMBL6929008;DTXSID80583306;SB38023

Suppliers and Price of 2-Methoxy-2-naphthalen-2-yl-propionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-Methoxy-2-naphthalen-2-yl-propionic acid

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:230.094294304
Heavy Atom Count:17
Complexity:289

Purity/Quality:: ≥95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C1=CC2=CC=CC=C2C=C1)(C(=O)O)OC

Technology Process of 2-Methoxy-2-naphthalen-2-yl-propionic acid

There total 1 articles about 2-Methoxy-2-naphthalen-2-yl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21473-01-8
2-naphthalenylmagnesium bromide

: 299397-14-1
(S)-(+)-2-methoxy-2-(2-naphthyl)propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 15 percent / tetrahydrofuran / 6 h / -78 °C

2: 60 percent / NaH / dimethylformamide / 1 h / 20 °C

3: 89 percent / NaOH; H₂O / methanol / Heating

With sodium hydroxide; water; sodium hydride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: Grignard reaction / 2: Methylation / 3: Hydrolysis;
DOI:10.1016/S0957-4166(00)00233-0

Reference yield: 87.0%

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 299397-14-1
(S)-(+)-2-methoxy-2-(2-naphthyl)propionic acid

: 1393722-19-4
(S)-2-methoxy-2-(2-naphthyl)-N-[(S)-1-(1-naphthyl)ethyl]propanamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 18h;
DOI:10.1039/c1ce05155e