N-aminopapaverinium mesitylenesulphate

Base Information

• Chemical Name: N-aminopapaverinium mesitylenesulphate
• CAS No.: 88205-38-3
• Molecular Formula: C₉H₁₁O₃S*C₂₀H₂₃N₂O₄
• Molecular Weight: 554.664
• Mol file: 88205-38-3.mol

Synonyms:N-aminopapaverinium mesitylenesulphate

Chemical Property of N-aminopapaverinium mesitylenesulphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N-aminopapaverinium mesitylenesulphate

There total 1 articles about N-aminopapaverinium mesitylenesulphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.4%

Papaverine (58-74-2) + mesitylenesulfonylhydroxylamine (36016-40-7) → N-aminopapaverinium mesitylenesulphate (88205-38-3)

Guidance literature:

In dichloromethane; at 0 ℃; for 1.5h;

DOI:10.1039/P19830002059

Reference yield: 72.0%

N-aminopapaverinium mesitylenesulphate (88205-38-3) → 2-amino-1-(3',4'-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (88205-33-8)

Guidance literature:

With sodium tetrahydroborate; In ethanol;

DOI:10.1039/P19830002059

Reference yield:

N-aminopapaverinium mesitylenesulphate (88205-38-3) → (3,4-dimethoxyphenyl)methanol (93-03-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 2.) 55percent aq. HI / 1.) aq. ethanol, 0 deg C, 20 min, 2.) ethanol

2: 57 percent / sodium borohydride / ethanol / 0.75 h

3: 1.) sodium hydride / 1.) THF, 1.5 h, 2.) 15 min

4: 73.8 percent / acetone / 69 h / Heating

5: 2.) sodium borohydride / 1.) methanol, irradiation, 3 h, 2.) 98percent aq. EtOH, heating

With sodium tetrahydroborate; hydrogen iodide; sodium hydride; In ethanol; acetone;

DOI:10.1039/P19830002059

upstream raw materials:

Papaverine

mesitylenesulfonylhydroxylamine

Downstream raw materials:

N-acetamidopapaverinium iodide

1-(3',4'-dimethoxybenzyl)-6,7-dimethoxy-2-(N-methylacetamido)isoquinolinium methyl sulphate

1-(3',4'-dimethoxybenzyl)-6,7-dimethoxy-2-(N-methylacetamido)isoquinolinium iodide

2-amino-1-(3',4'-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline