METHYL-N-BOC-4[(DIETHOXY-PHOSPHORYL)-DIFLUORO]METHYL PHENYLALANINE

Base Information

Chemical Name:METHYL-N-BOC-4[(DIETHOXY-PHOSPHORYL)-DIFLUORO]METHYL PHENYLALANINE
CAS No.:156017-43-5
Molecular Formula:C20H30 F2 N O7 P
Molecular Weight:465.431
Hs Code.:
Mol file:156017-43-5.mol

Synonyms:METHYL-N-BOC-4[(DIETHOXY-PHOSPHORYL)-DIFLUORO]METHYL PHENYLALANINE

Suppliers and Price of METHYL-N-BOC-4[(DIETHOXY-PHOSPHORYL)-DIFLUORO]METHYL PHENYLALANINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
METHYL-N-BOC-4-[(DIETHOXY-PHOSPHORYL)DIFLUORO]METHYL PHENYLALANINE 95.00%
5MG
$ 505.77

Total 2 raw suppliers

Chemical Property of METHYL-N-BOC-4[(DIETHOXY-PHOSPHORYL)-DIFLUORO]METHYL PHENYLALANINE

Chemical Property:

Boiling Point:544.9±50.0 °C(Predicted)
PKA:10.88±0.46(Predicted)
PSA：112.18000
Density:1.209±0.06 g/cm3(Predicted)
LogP:4.86460

Purity/Quality:

99% ^*data from raw suppliers

METHYL-N-BOC-4-[(DIETHOXY-PHOSPHORYL)DIFLUORO]METHYL PHENYLALANINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of METHYL-N-BOC-4[(DIETHOXY-PHOSPHORYL)-DIFLUORO]METHYL PHENYLALANINE

There total 12 articles about METHYL-N-BOC-4[(DIETHOXY-PHOSPHORYL)-DIFLUORO]METHYL PHENYLALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 65094-22-6
diethyl (bromodifluoromethyl)phosphonate

: 224824-22-0
(S)-(4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)phenyl)boronic acid

: 156017-43-5
(2S)-{4-[2-tert-butoxycarbonylamino-2-(methoxycarbonyl)-ethyl]-phenyl}difluoromethyl-phosphonic acid diethyl ester

Guidance literature:: With bis(triphenylphosphine)palladium(II) dichloride; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 80 ℃;
DOI:10.1002/anie.201309535

Reference yield:

: 103882-09-3,62129-44-6
N-Boc-4-I-Phe-OH

: 156017-43-5
(2S)-{4-[2-tert-butoxycarbonylamino-2-(methoxycarbonyl)-ethyl]-phenyl}difluoromethyl-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; tetrahydrofuran; diethyl ether / 0 °C

2: 1.) Cd, 2.) CuCl / 1.) DMF, room temperature, 3.5 h, 2.) room temperature, 36 h

With copper(l) chloride; cadmium; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1016/S0040-4020(97)00374-8

Reference yield:

: 796072-33-8,210962-91-7
N-tert-butyloxycarbonyl-(L)4-iodophenylalanine methyl ester

: 156017-43-5
(2S)-{4-[2-tert-butoxycarbonylamino-2-(methoxycarbonyl)-ethyl]-phenyl}difluoromethyl-phosphonic acid diethyl ester

Guidance literature:: diethyl (bromodifluoromethyl)phosphonate; With acetic acid; cadmium; In N,N-dimethyl-formamide; at 20 ℃; for 3.9 - 4.06667h;

N-tert-butyloxycarbonyl-(L)4-iodophenylalanine methyl ester; With copper(l) chloride; In N,N-dimethyl-formamide; for 66h;