3R-(6-benzyloxy-7-methoxy-1H-indol-3-ylmethyl)-8aR-[4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-but-2-enyl]-1-methoxy-8S-methyl-6,7,8,8a-tetrahydro-3H-pyrrolo[1,2-a]pyrazin-4-one

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Chemical Name:3R-(6-benzyloxy-7-methoxy-1H-indol-3-ylmethyl)-8aR-[4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-but-2-enyl]-1-methoxy-8S-methyl-6,7,8,8a-tetrahydro-3H-pyrrolo[1,2-a]pyrazin-4-one
CAS No.:1154527-46-4
Molecular Formula:C₃₇H₅₁N₃O₅Si
Molecular Weight:645.915
Hs Code.:

3R-(6-benzyloxy-7-methoxy-1H-indol-3-ylmethyl)-8aR-[4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-but-2-enyl]-1-methoxy-8S-methyl-6,7,8,8a-tetrahydro-3H-pyrrolo[1,2-a]pyrazin-4-one

Synonyms:3R-(6-benzyloxy-7-methoxy-1H-indol-3-ylmethyl)-8aR-[4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-but-2-enyl]-1-methoxy-8S-methyl-6,7,8,8a-tetrahydro-3H-pyrrolo[1,2-a]pyrazin-4-one

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Chemical Property of 3R-(6-benzyloxy-7-methoxy-1H-indol-3-ylmethyl)-8aR-[4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-but-2-enyl]-1-methoxy-8S-methyl-6,7,8,8a-tetrahydro-3H-pyrrolo[1,2-a]pyrazin-4-one

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Technology Process of 3R-(6-benzyloxy-7-methoxy-1H-indol-3-ylmethyl)-8aR-[4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-but-2-enyl]-1-methoxy-8S-methyl-6,7,8,8a-tetrahydro-3H-pyrrolo[1,2-a]pyrazin-4-one

There total 2 articles about 3R-(6-benzyloxy-7-methoxy-1H-indol-3-ylmethyl)-8aR-[4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-but-2-enyl]-1-methoxy-8S-methyl-6,7,8,8a-tetrahydro-3H-pyrrolo[1,2-a]pyrazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1154527-45-3
3-(6-benzyloxy-7-methoxy-1H-indol-3-ylmethyl)-8a-[4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-but-2-enyl]-8-methyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

: 420-37-1
trimethoxonium tetrafluoroborate

: 1154527-46-4
3R-(6-benzyloxy-7-methoxy-1H-indol-3-ylmethyl)-8aR-[4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-but-2-enyl]-1-methoxy-8S-methyl-6,7,8,8a-tetrahydro-3H-pyrrolo[1,2-a]pyrazin-4-one

Guidance literature:: With caesium carbonate; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1016/j.tet.2008.08.102

Reference yield: 48.0%

: 3-(6-benzyloxy-7-methoxy-1H-indol-3-ylmethyl)-8a-[4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-but-2-enyl]-8-methyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

: 420-37-1
trimethoxonium tetrafluoroborate

: 1154527-27-1
3S-(6-benzyloxy-7-methoxy-1H-indol-3-ylmethyl)-8aR-[4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-but-2-enyl]-1-methoxy-8S-methyl-6,7,8,8a-tetrahydro-3H-pyrrolo[1,2-a]pyrazin-4-one

: 1154527-46-4
3R-(6-benzyloxy-7-methoxy-1H-indol-3-ylmethyl)-8aR-[4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-but-2-enyl]-1-methoxy-8S-methyl-6,7,8,8a-tetrahydro-3H-pyrrolo[1,2-a]pyrazin-4-one

Guidance literature:: 3-(6-benzyloxy-7-methoxy-1H-indol-3-ylmethyl)-8a-[4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-but-2-enyl]-8-methyl-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione; With caesium carbonate; In dichloromethane; at 20 ℃; for 0.5h;

trimethoxonium tetrafluoroborate; In dichloromethane; at 20 ℃; for 20h;

With water; sodium hydrogencarbonate; In dichloromethane;
DOI:10.1016/j.tet.2008.08.102