3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-N-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-propionamide

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Chemical Name:3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-N-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-propionamide
CAS No.:212578-63-7
Molecular Formula:C₃₃H₃₂F₂N₂O₃
Molecular Weight:542.625
Hs Code.:

Synonyms:3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-N-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-propionamide

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Chemical Property of 3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-N-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-propionamide

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Technology Process of 3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-N-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-propionamide

There total 3 articles about 3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-N-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 50366-32-0
2-[bis(p-fluorophenyl)-methoxy]ethylamine

: 212578-60-4
3-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)propionic acid

: 212578-63-7
3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-N-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-propionamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 5h; Ambient temperature;
DOI:10.1021/jm970795t

Reference yield:

: (E)-3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-acrylic acid ethyl ester

: 212578-63-7
3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-N-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / H₂ / Raney Ni / ethanol; H₂O / 4 h / 20 °C / 2585.7 Torr

2: 98 percent / KOH / ethanol / Heating

3: 84 percent / EDCI / CH₂Cl₂ / 5 h / Ambient temperature

With potassium hydroxide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; nickel; In ethanol; dichloromethane; water;
DOI:10.1021/jm970795t

Reference yield:

: 212578-72-8
3-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)propionic acid ethyl ester

: 212578-63-7
3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-N-{2-[bis-(4-fluoro-phenyl)-methoxy]-ethyl}-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / KOH / ethanol / Heating

2: 84 percent / EDCI / CH₂Cl₂ / 5 h / Ambient temperature

With potassium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1021/jm970795t