C₂₄H₁₉F₃N₆O

Base Information

• Chemical Name: C₂₄H₁₉F₃N₆O
• CAS No.: 1089725-67-6
• Molecular Formula: C₂₄H₁₉F₃N₆O
• Molecular Weight: 464.45
• Mol file: 1089725-67-6.mol

Synonyms:C₂₄H₁₉F₃N₆O

Chemical Property of C₂₄H₁₉F₃N₆O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₁₉F₃N₆O

There total 7 articles about C₂₄H₁₉F₃N₆O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid (641569-94-0) + 2-(trifluoromethyl)-1,4-phenylenediamine (364-13-6) → C24H19F3N6O (1089725-67-6)

Guidance literature:

4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; for 0.5h; Inert atmosphere; Cooling with ice;

2-(trifluoromethyl)-1,4-phenylenediamine; In tetrahydrofuran; at 0 - 20 ℃; for 24.5h; Inert atmosphere;

DOI:10.2147/DDDT.S211907

Reference yield:

3-amino-4-methylbenzoic acid ethyl ester (41191-92-8) → C24H19F3N6O (1089725-67-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride / ethanol; water

1.2: 1.5 h / 70 °C

2.1: potassium carbonate / propan-1-ol / 24 h / Reflux

3.1: sodium hydroxide / dichloromethane; methanol / 20 °C

4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 0.5 h / Inert atmosphere; Cooling with ice

4.2: 24.5 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; propan-1-ol; ethanol; dichloromethane; water;

DOI:10.2147/DDDT.S211907

Reference yield:

C34H35F3N6O5 (1089725-66-5) → C24H19F3N6O (1089725-67-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h;

upstream raw materials:

C₃₄H₃₅F₃N₆O₅

3-amino-4-methylbenzoic acid ethyl ester

4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester

4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid