C-7,C-10-dibenzyloxycarbonyl-10-deacetyl baccatin III

Base Information

• Chemical Name: C-7,C-10-dibenzyloxycarbonyl-10-deacetyl baccatin III
• CAS No.: 194864-02-3
• Molecular Formula: C₄₅H₄₈O₁₄
• Molecular Weight: 812.868
• Mol file: 194864-02-3.mol

Synonyms:C-7,C-10-dibenzyloxycarbonyl-10-deacetyl baccatin III

Chemical Property of C-7,C-10-dibenzyloxycarbonyl-10-deacetyl baccatin III

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C-7,C-10-dibenzyloxycarbonyl-10-deacetyl baccatin III

There total 1 articles about C-7,C-10-dibenzyloxycarbonyl-10-deacetyl baccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

10-deacetylbaccatin III (32981-86-5,172018-16-5) + benzyl chloroformate (501-53-1,94274-21-2) → C-7,C-10-dibenzyloxycarbonyl-10-deacetyl baccatin III (194864-02-3)

Guidance literature:

With dmap; In tetrahydrofuran; at 40 - 50 ℃;

Reference yield: 100.0%

C-7,C-10-dibenzyloxycarbonyl-10-deacetyl baccatin III (194864-02-3) → C66H77NO20

Guidance literature:

C₂₆H₃₉NO₈; With 4-methyl-morpholine; pivaloyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

C-7,C-10-dibenzyloxycarbonyl-10-deacetyl baccatin III; With dmap; In tetrahydrofuran; for 16h; Product distribution / selectivity; Heating / reflux;

Reference yield: 100.0%

C-7,C-10-dibenzyloxycarbonyl-10-deacetyl baccatin III (194864-02-3) + C26H39NO8 → C66H77NO20 (942485-87-2)

Guidance literature:

With 4-methyl-morpholine; dmap; pivaloyl chloride; In tetrahydrofuran; at 20 ℃; for 17h; Product distribution / selectivity; Heating / reflux;

upstream raw materials:

10-deacetylbaccatin III

benzyl chloroformate

Downstream raw materials:

13-(3'-N-benzyloxycarbonylphenylisoserine)-10-deacetyl-7,10-dibenzyloxycarbonylbaccatin III

13-(3'-N-benzyloxycarbonyl-2'-tert-butoxycarbonylphenylisoserine)-10-deacetyl-7,10-dibenzyloxycarbonylbaccatin III

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-amino-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

C₆₆H₇₇NO₂₀

Refernces

• 1、 -. "Method for preparing water-soluble texane derivatives and intermediates". Paragraph 0130; 0158-0160. . Retrieved 2017/09/02.
• 2、 -. "BIOLOGICALLY ACTIVE TAXANE ANALOGS AND METHODS OF TREATMENT BY ORAL ADMINISTRATION". Page/Page column 11-13. . Retrieved 2008/12/04.