(R)-tert-butyl 3-((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)-3-isopropyl-2-oxoindoline-1-carboxylate

Base Information

• Chemical Name: (R)-tert-butyl 3-((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)-3-isopropyl-2-oxoindoline-1-carboxylate
• CAS No.: 1043872-86-1
• Molecular Formula: C₂₈H₃₆N₂O₅
• Molecular Weight: 480.604
• Mol file: 1043872-86-1.mol

Synonyms:(R)-tert-butyl 3-((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)-3-isopropyl-2-oxoindoline-1-carboxylate

Chemical Property of (R)-tert-butyl 3-((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)-3-isopropyl-2-oxoindoline-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl 3-((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)-3-isopropyl-2-oxoindoline-1-carboxylate

There total 2 articles about (R)-tert-butyl 3-((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)-3-isopropyl-2-oxoindoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

tert-butyl 3-isopropyl-2-oxoindoline-1-carboxylate (923568-91-6) + benzaldehyde N-boc imine (150884-50-7) → (R)-tert-butyl 3-((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)-3-isopropyl-2-oxoindoline-1-carboxylate (1043872-86-1)

Guidance literature:

With 2,6-bis((4S,5S)-4-(methoxymethyl)-5-phenyl-4,5-dihydrooxazol-2-yl)pyridine; triethylamine; calcium iodide; In dichloromethane; at -78 ℃; for 18h; stereoselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.5b00749

Reference yield:

tert-butyl 3-isopropyl-2-oxoindoline-1-carboxylate (923568-91-6) + benzaldehyde N-boc imine (150884-50-7) → C28H36N2O5 + C28H36N2O5 + (R)-tert-butyl 3-((S)-((tert-butoxycarbonyl)amino)(phenyl)methyl)-3-isopropyl-2-oxoindoline-1-carboxylate (1043872-86-1)

Guidance literature:

With C₂₄H₂₄F₃N₃S; In m-xylene; at 5 - 10 ℃; for 72h; optical yield given as %ee; Molecular sieve;

DOI:10.1021/ol801351j

upstream raw materials:

tert-butyl 3-isopropyl-2-oxoindoline-1-carboxylate

benzaldehyde N-boc imine