ethyl 2,3-dideoxy-4-O-diphenylphosphino-6-O-trityl-α-D-threo-hex-2-enopyranoside

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Chemical Name:ethyl 2,3-dideoxy-4-O-diphenylphosphino-6-O-trityl-α-D-threo-hex-2-enopyranoside
CAS No.:1387444-07-6
Molecular Formula:C₃₉H₃₇O₄P
Molecular Weight:600.694
Hs Code.:

Synonyms:ethyl 2,3-dideoxy-4-O-diphenylphosphino-6-O-trityl-α-D-threo-hex-2-enopyranoside

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 2,3-dideoxy-4-O-diphenylphosphino-6-O-trityl-α-D-threo-hex-2-enopyranoside

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Technology Process of ethyl 2,3-dideoxy-4-O-diphenylphosphino-6-O-trityl-α-D-threo-hex-2-enopyranoside

There total 9 articles about ethyl 2,3-dideoxy-4-O-diphenylphosphino-6-O-trityl-α-D-threo-hex-2-enopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1079-66-9,74391-44-9
chloro-diphenylphosphine

: 55735-66-5,142344-18-1
ethyl 2,3-dideoxy-6-O-trityl-α-D-threo-hex-2-enopyranoside

: 1387444-07-6
ethyl 2,3-dideoxy-4-O-diphenylphosphino-6-O-trityl-α-D-threo-hex-2-enopyranoside

Guidance literature:: ethyl 2,3-dideoxy-6-O-trityl-α-D-threo-hex-2-enopyranoside; With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

chloro-diphenylphosphine; In tetrahydrofuran; at 20 ℃; for 0.666667h; Inert atmosphere;
DOI:10.1021/ol3015896

Reference yield:

: 69055-68-1,3323-72-6,56196-39-5,61826-47-9,63976-48-7,78148-04-6
ethyl 4,6-di-O-acetyl-2,3-dideoxy-α-D-threo-hex-2-enopyranoside

: 1387444-07-6
ethyl 2,3-dideoxy-4-O-diphenylphosphino-6-O-trityl-α-D-threo-hex-2-enopyranoside

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; triethylamine / methanol / 3 h / 20 °C

2.1: pyridine / 24 h / 20 °C

3.1: dmap; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

3.2: 0.67 h / 20 °C / Inert atmosphere

With pyridine; dmap; water; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1021/ol3015896

Reference yield:

: 142344-18-1,55735-66-5
ethyl 2,3-dideoxy-6-O-trityl-α-D-erythro-hex-2-enopyranoside

: 1387444-07-6
ethyl 2,3-dideoxy-4-O-diphenylphosphino-6-O-trityl-α-D-threo-hex-2-enopyranoside

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; diethylazodicarboxylate / toluene / 3 h / 20 °C

2.1: water; triethylamine / methanol / 16 h / 20 °C

3.1: dmap; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

3.2: 0.67 h / 20 °C / Inert atmosphere

With dmap; water; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; toluene; 1.1: Mitsunobu epimerisation;
DOI:10.1021/ol3015896