N-benzyl [5-chloro-2-(4-ethyl-phenylethynyl)-phenyl]phosphonamide monoethyl ester

Base Information

• Chemical Name: N-benzyl [5-chloro-2-(4-ethyl-phenylethynyl)-phenyl]phosphonamide monoethyl ester
• CAS No.: 915718-74-0
• Molecular Formula: C₂₅H₂₅ClNO₂P
• Molecular Weight: 437.906
• Mol file: 915718-74-0.mol

Synonyms:N-benzyl [5-chloro-2-(4-ethyl-phenylethynyl)-phenyl]phosphonamide monoethyl ester

Chemical Property of N-benzyl [5-chloro-2-(4-ethyl-phenylethynyl)-phenyl]phosphonamide monoethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl [5-chloro-2-(4-ethyl-phenylethynyl)-phenyl]phosphonamide monoethyl ester

There total 2 articles about N-benzyl [5-chloro-2-(4-ethyl-phenylethynyl)-phenyl]phosphonamide monoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H17Cl2O2P + benzylamine (100-46-9) → N-benzyl [5-chloro-2-(4-ethyl-phenylethynyl)-phenyl]phosphonamide monoethyl ester (915718-74-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/jo0614644

Reference yield:

[5-chloro-2-(4-ethylphenylethynyl)phenyl]phosphonic acid monoethyl ester (639517-08-1) → N-benzyl [5-chloro-2-(4-ethyl-phenylethynyl)-phenyl]phosphonamide monoethyl ester (915718-74-0)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / CH₂Cl₂ / 2 h / 20 °C

2: Et₃N / CH₂Cl₂ / 4 h / 20 °C

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1021/jo0614644

Reference yield: 88.0%

N-benzyl [5-chloro-2-(4-ethyl-phenylethynyl)-phenyl]phosphonamide monoethyl ester (915718-74-0) + allyl bromide (106-95-6) → C28H29ClNO2P (1088696-29-0)

Guidance literature:

With methyloxirane; dichloro bis(acetonitrile) palladium(II); In acetonitrile; at 80 ℃; for 4h;

DOI:10.1016/j.tet.2008.08.091

upstream raw materials:

benzylamine

[5-chloro-2-(4-ethylphenylethynyl)phenyl]phosphonic acid monoethyl ester

Downstream raw materials:

C₂₈H₂₉ClNO₂P