Sodium; (3R,5S)-6-{2-[(R)-cyclohexyl-(2,2-dimethyl-butyrylamino)-methyl]-4,6-dimethyl-phenoxy}-3,5-dihydroxy-hexanoate

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Chemical Name:Sodium; (3R,5S)-6-{2-[(R)-cyclohexyl-(2,2-dimethyl-butyrylamino)-methyl]-4,6-dimethyl-phenoxy}-3,5-dihydroxy-hexanoate
CAS No.:136006-58-1
Molecular Formula:C₂₇H₄₂NO₆*Na
Molecular Weight:499.623
Hs Code.:

Synonyms:Sodium; (3R,5S)-6-{2-[(R)-cyclohexyl-(2,2-dimethyl-butyrylamino)-methyl]-4,6-dimethyl-phenoxy}-3,5-dihydroxy-hexanoate

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Chemical Property of Sodium; (3R,5S)-6-{2-[(R)-cyclohexyl-(2,2-dimethyl-butyrylamino)-methyl]-4,6-dimethyl-phenoxy}-3,5-dihydroxy-hexanoate

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Technology Process of Sodium; (3R,5S)-6-{2-[(R)-cyclohexyl-(2,2-dimethyl-butyrylamino)-methyl]-4,6-dimethyl-phenoxy}-3,5-dihydroxy-hexanoate

There total 14 articles about Sodium; (3R,5S)-6-{2-[(R)-cyclohexyl-(2,2-dimethyl-butyrylamino)-methyl]-4,6-dimethyl-phenoxy}-3,5-dihydroxy-hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136006-74-1
N-{(R)-Cyclohexyl-[2-((2S,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-ylmethoxy)-3,5-dimethyl-phenyl]-methyl}-2,2-dimethyl-butyramide

: 136006-58-1
Sodium; (3R,5S)-6-{2-[(R)-cyclohexyl-(2,2-dimethyl-butyrylamino)-methyl]-4,6-dimethyl-phenoxy}-3,5-dihydroxy-hexanoate

Guidance literature:: With sodium hydroxide; In ethanol; at 20 - 25 ℃; for 1h;
DOI:10.1021/jm00114a004

Reference yield:

: 20654-46-0
2,2-dimethylbutyronitrile

: 136006-58-1
Sodium; (3R,5S)-6-{2-[(R)-cyclohexyl-(2,2-dimethyl-butyrylamino)-methyl]-4,6-dimethyl-phenoxy}-3,5-dihydroxy-hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 490 mg / 48percent aq. HF / 50 h / 25 °C

2: 73 percent / glacial acetic acid, tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 4 h / 20 °C

3: 1N NaOH / ethanol / 1 h / 20 - 25 °C

With sodium hydroxide; hydrogen fluoride; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00114a004

Reference yield:

: 110772-23-1
[(2S,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-methanol

: 136006-58-1
Sodium; (3R,5S)-6-{2-[(R)-cyclohexyl-(2,2-dimethyl-butyrylamino)-methyl]-4,6-dimethyl-phenoxy}-3,5-dihydroxy-hexanoate

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / pyridine / CH₂Cl₂ / 3 h / Ambient temperature

2: 90 percent / NaI / acetone / 24 h / Heating

3: 74 percent / K₂CO₃ / dimethylsulfoxide / 60 °C

4: 76 percent / glacial acetic acid / tetrahydrofuran / Heating

5: tetra-n-butylammonium iodide, N-iodosuccinimide / CH₂Cl₂ / 20 h / Ambient temperature

6: 490 mg / 48percent aq. HF / 50 h / 25 °C

7: 73 percent / glacial acetic acid, tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 4 h / 20 °C

8: 1N NaOH / ethanol / 1 h / 20 - 25 °C

With pyridine; sodium hydroxide; N-iodo-succinimide; hydrogen fluoride; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; potassium carbonate; acetic acid; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; acetone;
DOI:10.1021/jm00114a004