methyl 3-(2,4-dichlorophenyl)-6-{[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}pyrazine-2-carboxylate

Base Information

Chemical Name:methyl 3-(2,4-dichlorophenyl)-6-{[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}pyrazine-2-carboxylate
CAS No.:535938-26-2
Molecular Formula:C₂₁H₁₇Cl₂N₃O₃
Molecular Weight:430.29
Hs Code.:

Synonyms:methyl 3-(2,4-dichlorophenyl)-6-{[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}pyrazine-2-carboxylate

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Chemical Property of methyl 3-(2,4-dichlorophenyl)-6-{[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}pyrazine-2-carboxylate

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Technology Process of methyl 3-(2,4-dichlorophenyl)-6-{[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}pyrazine-2-carboxylate

There total 4 articles about methyl 3-(2,4-dichlorophenyl)-6-{[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}pyrazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 535938-24-0
methyl 3-bromo-6-{[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}pyrazine-2-carboxylate

: 68716-47-2
2,4-dichlorophenylboronic acid

: 535938-26-2
methyl 3-(2,4-dichlorophenyl)-6-{[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}pyrazine-2-carboxylate

Guidance literature:: With sodium carbonate; Pd(PPh₃)4; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 535938-20-6
(1R,2S)-1-[(6-chloropyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol

: 535938-26-2
methyl 3-(2,4-dichlorophenyl)-6-{[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}pyrazine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: carbon monoxide; triethylamine / PdCl₂(PhCN)2; silica gel / methanol; ethyl acetate

2: dichloromethane; ethyl acetate

3: sodium carbonate / Pd(PPh₃)4 / ethyl acetate; N,N-dimethyl-formamide

With carbon monoxide; sodium carbonate; triethylamine; Pd(PPh₃)4; PdCl₂(PhCN)2; silica gel; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 535938-22-8
methyl 6-{[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}pyrazine-2-carboxylate

: 535938-26-2
methyl 3-(2,4-dichlorophenyl)-6-{[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}pyrazine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane; ethyl acetate

2: sodium carbonate / Pd(PPh₃)4 / ethyl acetate; N,N-dimethyl-formamide

With sodium carbonate; Pd(PPh₃)4; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;