4-benzoyl-5-(4-bromophenyl)-1-(2-ethoxy-4-(trifluoromethyl)phenyl)-3-isopropoxy-1H-pyrrol-2(5H)-one

Base Information

Chemical Name:4-benzoyl-5-(4-bromophenyl)-1-(2-ethoxy-4-(trifluoromethyl)phenyl)-3-isopropoxy-1H-pyrrol-2(5H)-one
CAS No.:1610599-79-5
Molecular Formula:C₃₀H₂₇BrF₃NO₄
Molecular Weight:602.448
Hs Code.:

Synonyms:4-benzoyl-5-(4-bromophenyl)-1-(2-ethoxy-4-(trifluoromethyl)phenyl)-3-isopropoxy-1H-pyrrol-2(5H)-one

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Chemical Property of 4-benzoyl-5-(4-bromophenyl)-1-(2-ethoxy-4-(trifluoromethyl)phenyl)-3-isopropoxy-1H-pyrrol-2(5H)-one

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Technology Process of 4-benzoyl-5-(4-bromophenyl)-1-(2-ethoxy-4-(trifluoromethyl)phenyl)-3-isopropoxy-1H-pyrrol-2(5H)-one

There total 4 articles about 4-benzoyl-5-(4-bromophenyl)-1-(2-ethoxy-4-(trifluoromethyl)phenyl)-3-isopropoxy-1H-pyrrol-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1610600-03-7
C₂₇H₂₁BrF₃NO₄

: 67-63-0,8013-70-5
isopropyl alcohol

: 1610599-79-5
4-benzoyl-5-(4-bromophenyl)-1-(2-ethoxy-4-(trifluoromethyl)phenyl)-3-isopropoxy-1H-pyrrol-2(5H)-one

Guidance literature:: C₂₇H₂₁BrF₃NO₄; With triphenylphosphine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

isopropyl alcohol; With di-isopropyl azodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmcl.2014.04.063

Reference yield:

: 146070-34-0
2-fluoro-4-(trifluoromethyl)benzonitrile

: 1610599-79-5
4-benzoyl-5-(4-bromophenyl)-1-(2-ethoxy-4-(trifluoromethyl)phenyl)-3-isopropoxy-1H-pyrrol-2(5H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / 12 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / 12 h / 0 - 20 °C

3.1: 1,4-dioxane / 0.17 h / 20 °C

3.2: 12 h

4.1: triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

4.2: 12 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/j.bmcl.2014.04.063

Reference yield:

: 1610600-00-4
C₁₀H₁₂F₃NO

: 1610599-79-5
4-benzoyl-5-(4-bromophenyl)-1-(2-ethoxy-4-(trifluoromethyl)phenyl)-3-isopropoxy-1H-pyrrol-2(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,4-dioxane / 0.17 h / 20 °C

1.2: 12 h

2.1: triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

2.2: 12 h / 0 - 20 °C / Inert atmosphere

With triphenylphosphine; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/j.bmcl.2014.04.063